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Sci Rep：CXCL12可显著增强牙周膜干细胞的血管发生

2017-09-29 MedSci MedSci原创

CXCL12牙周膜干细胞组织工程
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牙周膜干细胞（PDLSCs）是成人间质干细胞（MSC）的主要来源，对组织工程中发挥巨大作用，如促进血管生成和骨再生。据研究报道，CXCL12参与伤口部位的MSC的募集和移植。然而，CXCL12是否可增强PDLSCs的血管发生目前则并不明确。在本实验中，研究人员使用CXCL12转导PDLSCs，并通过体外和体内研究评估CXCL12修饰的PDLSCs的血管生成的潜力。结果表明，CXCL12过表达可显著

牙周膜干细胞（PDLSCs）是成人间质干细胞（MSC）的主要来源，对组织工程中发挥巨大作用，如促进血管生成和骨再生。据研究报道，CXCL12参与伤口部位的MSC的募集和移植。然而，CXCL12是否可增强PDLSCs的血管发生目前则并不明确。

在本实验中，研究人员使用CXCL12转导PDLSCs，并通过体外和体内研究评估CXCL12修饰的PDLSCs的血管生成的潜力。结果表明，CXCL12过表达可显著刺激PDLSCs中bFGF、VEGF、SCF和PLGF的基因和蛋白表达；CXCL12基因修饰的PDLSCs可形成较长的毛细血管样结构；此外，用CXCL12转导的PDLSCs体内移植发现可显著促进颅骨缺损大鼠模型中的骨组织修复和血管生成。

总之，该研究结果证实，CXCL12可以增强PDLSCs的血管生成能力，这对于骨组织的修复和再生是至关重要的。

原始出处：

Lei Zhang, Yong Zhou, et al. CXCL12 overexpression promotes the angiogenesis potential of periodontal ligament stem cells. Sci Rep. 2017; 7: 10286. Published online 2017 Aug 31. doi: 10.1038/s41598-017-10971-1

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    2018-07-20 xue8602

    #牙周膜干细胞#

    0

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    2018-06-09 xqptu

    #牙周膜#

    0

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    2017-12-09 柳叶一刀

    #血管发生#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2037121, encodeId=d4b9203e121c1, content=<a href='/topic/show?id=7e536e53866' target=_blank style='color:#2F92EE;'>#牙周膜干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67538, encryptionId=7e536e53866, topicName=牙周膜干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Fri Jul 20 14:36:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755874, encodeId=f9901e5587419, content=<a href='/topic/show?id=30f46e536d7' target=_blank style='color:#2F92EE;'>#牙周膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67536, encryptionId=30f46e536d7, topicName=牙周膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a6e37060729, createdName=xqptu, createdTime=Sat Jun 09 09:36:00 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1976523, encodeId=062619e65236e, content=<a href='/topic/show?id=ea788958863' target=_blank style='color:#2F92EE;'>#血管发生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89588, encryptionId=ea788958863, topicName=血管发生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Dec 09 03:36:00 CST 2017, time=2017-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783987, encodeId=fb591e839876e, content=<a href='/topic/show?id=aa8d553574' target=_blank style='color:#2F92EE;'>#CXCL1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5535, encryptionId=aa8d553574, topicName=CXCL1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Sun Feb 25 07:36:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250753, encodeId=e450250e53e4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/1dd9eb6c80e2bb55ba480da2b25b4781.jpg, createdBy=97e71637829, createdName=yanxqbsz, createdTime=Fri Oct 06 09:07:33 CST 2017, time=2017-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450656, encodeId=aea7145065625, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sun Oct 01 11:36:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249118, encodeId=a7ba249118e5, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/1dd9eb6c80e2bb55ba480da2b25b4781.jpg, createdBy=97e71637829, createdName=yanxqbsz, createdTime=Sat Sep 30 15:03:55 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248967, encodeId=5f5d24896e04, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Sat Sep 30 05:23:40 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248875, encodeId=294c2488e5fe, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Fri Sep 29 20:49:03 CST 2017, time=2017-09-29, status=1, ipAttribution=)]
    2018-02-25 wetgdt

    #CXCL1#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2037121, encodeId=d4b9203e121c1, content=<a href='/topic/show?id=7e536e53866' target=_blank style='color:#2F92EE;'>#牙周膜干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67538, encryptionId=7e536e53866, topicName=牙周膜干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Fri Jul 20 14:36:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755874, encodeId=f9901e5587419, content=<a href='/topic/show?id=30f46e536d7' target=_blank style='color:#2F92EE;'>#牙周膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67536, encryptionId=30f46e536d7, topicName=牙周膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a6e37060729, createdName=xqptu, createdTime=Sat Jun 09 09:36:00 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1976523, encodeId=062619e65236e, content=<a href='/topic/show?id=ea788958863' target=_blank style='color:#2F92EE;'>#血管发生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89588, encryptionId=ea788958863, topicName=血管发生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Dec 09 03:36:00 CST 2017, time=2017-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783987, encodeId=fb591e839876e, content=<a href='/topic/show?id=aa8d553574' target=_blank style='color:#2F92EE;'>#CXCL1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5535, encryptionId=aa8d553574, topicName=CXCL1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Sun Feb 25 07:36:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250753, encodeId=e450250e53e4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/1dd9eb6c80e2bb55ba480da2b25b4781.jpg, createdBy=97e71637829, createdName=yanxqbsz, createdTime=Fri Oct 06 09:07:33 CST 2017, time=2017-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450656, encodeId=aea7145065625, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sun Oct 01 11:36:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249118, encodeId=a7ba249118e5, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/1dd9eb6c80e2bb55ba480da2b25b4781.jpg, createdBy=97e71637829, createdName=yanxqbsz, createdTime=Sat Sep 30 15:03:55 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248967, encodeId=5f5d24896e04, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Sat Sep 30 05:23:40 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248875, encodeId=294c2488e5fe, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Fri Sep 29 20:49:03 CST 2017, time=2017-09-29, status=1, ipAttribution=)]
    2017-10-06 yanxqbsz

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2037121, encodeId=d4b9203e121c1, content=<a href='/topic/show?id=7e536e53866' target=_blank style='color:#2F92EE;'>#牙周膜干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67538, encryptionId=7e536e53866, topicName=牙周膜干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Fri Jul 20 14:36:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755874, encodeId=f9901e5587419, content=<a href='/topic/show?id=30f46e536d7' target=_blank style='color:#2F92EE;'>#牙周膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67536, encryptionId=30f46e536d7, topicName=牙周膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a6e37060729, createdName=xqptu, createdTime=Sat Jun 09 09:36:00 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1976523, encodeId=062619e65236e, content=<a href='/topic/show?id=ea788958863' target=_blank style='color:#2F92EE;'>#血管发生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89588, encryptionId=ea788958863, topicName=血管发生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Dec 09 03:36:00 CST 2017, time=2017-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783987, encodeId=fb591e839876e, content=<a href='/topic/show?id=aa8d553574' target=_blank style='color:#2F92EE;'>#CXCL1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5535, encryptionId=aa8d553574, topicName=CXCL1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Sun Feb 25 07:36:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250753, encodeId=e450250e53e4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/1dd9eb6c80e2bb55ba480da2b25b4781.jpg, createdBy=97e71637829, createdName=yanxqbsz, createdTime=Fri Oct 06 09:07:33 CST 2017, time=2017-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450656, encodeId=aea7145065625, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sun Oct 01 11:36:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249118, encodeId=a7ba249118e5, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/1dd9eb6c80e2bb55ba480da2b25b4781.jpg, createdBy=97e71637829, createdName=yanxqbsz, createdTime=Sat Sep 30 15:03:55 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248967, encodeId=5f5d24896e04, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Sat Sep 30 05:23:40 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248875, encodeId=294c2488e5fe, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Fri Sep 29 20:49:03 CST 2017, time=2017-09-29, status=1, ipAttribution=)]
    2017-10-01 liuyong2982

    #牙周#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2037121, encodeId=d4b9203e121c1, content=<a href='/topic/show?id=7e536e53866' target=_blank style='color:#2F92EE;'>#牙周膜干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67538, encryptionId=7e536e53866, topicName=牙周膜干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Fri Jul 20 14:36:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755874, encodeId=f9901e5587419, content=<a href='/topic/show?id=30f46e536d7' target=_blank style='color:#2F92EE;'>#牙周膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67536, encryptionId=30f46e536d7, topicName=牙周膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a6e37060729, createdName=xqptu, createdTime=Sat Jun 09 09:36:00 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1976523, encodeId=062619e65236e, content=<a href='/topic/show?id=ea788958863' target=_blank style='color:#2F92EE;'>#血管发生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89588, encryptionId=ea788958863, topicName=血管发生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Dec 09 03:36:00 CST 2017, time=2017-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783987, encodeId=fb591e839876e, content=<a href='/topic/show?id=aa8d553574' target=_blank style='color:#2F92EE;'>#CXCL1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5535, encryptionId=aa8d553574, topicName=CXCL1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Sun Feb 25 07:36:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250753, encodeId=e450250e53e4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/1dd9eb6c80e2bb55ba480da2b25b4781.jpg, createdBy=97e71637829, createdName=yanxqbsz, createdTime=Fri Oct 06 09:07:33 CST 2017, time=2017-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450656, encodeId=aea7145065625, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sun Oct 01 11:36:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249118, encodeId=a7ba249118e5, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/1dd9eb6c80e2bb55ba480da2b25b4781.jpg, createdBy=97e71637829, createdName=yanxqbsz, createdTime=Sat Sep 30 15:03:55 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248967, encodeId=5f5d24896e04, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Sat Sep 30 05:23:40 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248875, encodeId=294c2488e5fe, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Fri Sep 29 20:49:03 CST 2017, time=2017-09-29, status=1, ipAttribution=)]
    2017-09-30 yanxqbsz

    感谢分享

    0

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    2017-09-30 狼毒花1982

    学习了感谢分享

    0

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    2017-09-29 狼毒花1982

    学习了感谢分享

    0