BMJ:究竟多少体力活动才能做到降低疾病风险?——荟萃分析

2016-08-10 fsy 译 MedSci原创

该研究的目的是量化总体力活动与乳腺癌、结肠癌、糖尿病、缺血性心脏病和缺血性脑卒中事件之间的剂量-反应关系。原始出处:Hmwe H Kyu,Victoria F Bachman,Lily T Alexander,et al.Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disea

该研究的目的是量化总体力活动与乳腺癌、结肠癌、糖尿病、缺血性心脏病和缺血性脑卒中事件之间的剂量-反应关系。

来自美国的研究人员进行了一项系统评价和贝叶斯剂量反应荟萃分析。

研究人员检索了从1980年到2016年2月27日的PubMed和Embase,以及相关的系统研究文献。数据来源于全球老龄化与成人健康研究,该研究于2007年至2010年期间在中国、加纳、印度、墨西哥、俄罗斯和南非进行。研究人员使用1999年至2011年的美国全国健康和营养调查来描述特定领域的体力活动(纳入研究中的报告)与总体力活动。

该荟萃分析纳入的研究标准为前瞻性队列研究,并且这些研究探讨了体力活动(任何领域)和五种疾病中至少一种疾病之间的关联。

研究人员共确定了174篇文章:35篇关于乳腺癌,19篇关于结肠癌,55篇关于糖尿病,43篇关于缺血性心脏疾病,26篇关于缺血性中风(还有一些文章包括多个结果)。虽然更高水平的总体力活动可以降低所有结果的风险,但具有较低水平体力活动(3000-4000代谢当量[MET]分钟/周)的人群受益较多。例如,与没有体力活动的人群相比,体力活动量为600 MET分钟/周(建议的最低水平)的人群患有糖尿病的风险下降2%。从600增加至3600 MET分钟/周,可降低19%的疾病风险。对于活动量较大的人群,增加相同的活动量后并没有降低太多的疾病风险:总活动量从9000增加到12000 MET分钟/周,患糖尿病的危险仅减少0.6%。与活动量较少的人群相比(总活动量<600 MET分钟/周),活动量大的人群(≥8000 MET分钟/周)乳腺癌风险降低14%(相对危险度0.863,95%的不确定性区间 0.829至0.900);结肠癌风险降低21%(0.789,0.735至0.850);糖尿病风险降低28%(0.722,0.678至0.768);缺血性心脏疾病风险降低25%(0.754,0.704至0.809);缺血性卒中风险降低26%(0.736,0.659至0.811)。

总体力活动水平高出当前推荐的最低水平几倍的人群,五种疾病的风险显著减少。详细定量总体力活动的更多的研究将有助于针对不同水平的体力活动进行更精确的相对风险评估。

原始出处:


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    2017-02-18 gaoxiaoe
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    2017-05-09 venlin
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    2016-09-11 1e10c84am36(暂无匿称)

    己拜读,受益匪浅

    0

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