Acta Anaesthesiol Scand:论如何改善肥胖手术患者的氧和作用

2015-08-30 MedSci MedSci原创

对肥胖患者来说,麻醉诱导的肺不张以及气道闭塞现象是很常见的,而肺不张和气道阻塞引起的静脉血掺杂,可影响肺通气血流比值,并进而阻碍全麻期间机体的氧合作用。近期,瑞典乌普萨拉大学的研究人员,对预充氧期间使用持续气道正压通气(CPAP)以及在麻醉苏醒期降低吸入氧浓度(FI02),是否可以提高进行腹腔镜手术的肥胖患者的氧合作用进行了探讨。 本次研究将患者随机分为2组:干预组(n=20, 

对肥胖患者来说,麻醉诱导的肺不张以及气道闭塞现象是很常见的,而肺不张和气道阻塞引起的静脉血掺杂,可影响肺通气血流比值,并进而阻碍全麻期间机体的氧合作用。近期,瑞典乌普萨拉大学的研究人员,对预充氧期间使用持续气道正压通气(CPAP)以及在麻醉苏醒期降低吸入氧浓度(FI02),是否可以提高进行腹腔镜手术的肥胖患者的氧合作用进行了探讨。

本次研究将患者随机分为2组:干预组(n=20, 平均 BMI为 41.9),在预充氧以及麻醉诱导期间使用10cmH2O的持续气道正压通气;对照组(n=20, 平均BMI为38.1),在预充氧以及麻醉诱导期间未使用持续气道正压通气。在麻醉期间,所有患者使用容量控制模式进行通气:吸入氧浓度为0.4,呼气末正压通气(PEEP)为10 cmH2O。麻醉苏醒期:在拔管前,给予控制组患者的吸入氧浓度为1.0,并进一步将干预组分为2个小组,给与患者的吸入氧浓度分别为1.0和0.31。通过估算静脉血掺杂(EVA)对患者围术期氧合作用进行评估。


结果显示,在预充氧前两组患者的平均EVA大约为8%。麻醉插管后,干预组患者的平均EVA为8.2%,控制组患者的平均EVA为13.2% (P = 0.048)。在进行二氧化碳气腹后,干预组患者的平均EVA为8.4%,控制组患者的平均EVA为9.9% (P>0.05)。在术后一小时内,吸入氧浓度为1.0的患者在苏醒期出现氧合作用的恶化,而吸入氧浓度为0.31的患者的氧合作用则没有出现下降的现象。

本研究表明:在预充氧和麻醉诱导期对患者进行持续气道正压通气(10cmH2O),随后在插管后进行呼气末正压通气,似乎可以有效维持患者麻醉期间的氧合作用;而患者术后的氧合作用则取决于麻醉苏醒期的吸入氧浓度。

原始出处:

L.Edmark1, E.Ostberg1 et al.Preserved oxygenation in obese patients receiving protective ventilation during laparoscopic surgery:a randomized  controlled study. Acta Anaesthesiol Scand. 2015 Aug 3

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  1. [GetPortalCommentsPageByObjectIdResponse(id=127153, encodeId=5af612e153fd, content=文章不错,值得拜读, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Sep 15 07:37:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47973, encodeId=90b84e973f6, content=值得看,好好收藏,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 14:06:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633338, encodeId=52c5163333884, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Sun Jan 10 00:09:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849512, encodeId=22ee184951234, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Thu Mar 10 22:09:00 CST 2016, time=2016-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050490, encodeId=8e09205049011, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Dec 02 22:09:00 CST 2015, time=2015-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588201, encodeId=1bcc1588201c1, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Tue Sep 01 13:09:00 CST 2015, time=2015-09-01, status=1, ipAttribution=)]
    2016-09-15 1e10c84am36(暂无匿称)

    文章不错,值得拜读

    0

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    2015-12-26 hixiaoluo

    值得看,好好收藏,谢谢分享

    0

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    2016-01-10 AspirantSuo
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    2016-03-10 windight
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    2015-09-01 skhzy

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