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Clinica Chimica Acta：应用IFN-γ/ FluoroSpot - 2试验区分活动性结核病和非肺结核

2019-12-21 MedSci MedSci原创

动性结核病
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当前，一些可用的干扰素-γ释放检测方法不能可靠地区分活动性结核病（ATB）和非活动性结核病（non-ATB）。本研究旨在评估的诊断准确性IFN-γ/ FluoroSpot - 2试验，可同时检测IFN-γ- 2分泌，从而区分non-ATB。

当前，一些可用的干扰素-γ释放检测方法不能可靠地区分活动性结核病（ATB）和非活动性结核病（non-ATB）。本研究旨在评估的诊断准确性IFN-γ/ FluoroSpot - 2试验，可同时检测IFN-γ- 2分泌，从而区分non-ATB。

本研究连续招募了191名疑似T-SPOT阳性的ATB患者。 64名（33.5％）参与者患有ATB，包括22项（34.4％）经微生物或组织学证实的结核病和42例（65.6％）临床诊断为TB。非ATB 119例（62.3％），临床不确定8例（4.2％）。在被ESAT-6和CFP-10抗原刺激后，ATB组中IFN-γ+ IL-2-T细胞的中位频率和比例显著高于非ATB组（P <0.001）。 IFN-γ+ IL-2-T细胞的ROC曲线下面积大于总IFN-γ+ T细胞的面积（0.788对0.739，p = 0.323）。截止频率为25个SFC / 250,000个PBMC，该测定的灵敏度和特异性分别为73.4％和69.8％。当结合IFN-γ+ IL-2-T细胞的频率和比例时，平行试验的敏感性和特异性分别提高到95.3％和连续试验的83.2％。

综上所述，IFN-γ/ IL-2 FluoroSpot检测有助于诊断T-SPOT.TB结果阳性的ATB。

原始出处：

Lifan Zhang，Shijun Wan，Application of IFN-γ/IL-2 FluoroSpot assay for distinguishing active tuberculosis from non-active tuberculosis: A cohort study

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1723988, encodeId=6b711e23988ba, content=<a href='/topic/show?id=2d996516e7c' target=_blank style='color:#2F92EE;'>#活动性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65167, encryptionId=2d996516e7c, topicName=活动性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596833562866, createdName=楚秀娟, createdTime=Sun Sep 06 03:40:00 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068127, encodeId=b4d1206812e18, content=<a href='/topic/show?id=bc1616639f0' target=_blank style='color:#2F92EE;'>#Spot#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16639, encryptionId=bc1616639f0, topicName=Spot)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Fri Nov 27 08:40:00 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849824, encodeId=4230184982427, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Sep 23 01:40:00 CST 2020, time=2020-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1254318, encodeId=6850125431876, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Mon Dec 23 03:40:00 CST 2019, time=2019-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364554, encodeId=1cd3136455495, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Mon Dec 23 03:40:00 CST 2019, time=2019-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519047, encodeId=a47a151904e31, content=<a href='/topic/show?id=ba989452f5' target=_blank style='color:#2F92EE;'>#IFN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9452, encryptionId=ba989452f5, topicName=IFN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b711235060, createdName=bugit, createdTime=Mon Dec 23 03:40:00 CST 2019, time=2019-12-23, status=1, ipAttribution=)]
    2020-09-06 楚秀娟

    #活动性#

    0

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    2020-11-27 仁心济世

    #Spot#

    0

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    2020-09-23 windight

    #CTA#

    0

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    2019-12-23 huhuaidong387

    #结核#

    0

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    2019-12-23 lsndxfj

    #ROS#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1723988, encodeId=6b711e23988ba, content=<a href='/topic/show?id=2d996516e7c' target=_blank style='color:#2F92EE;'>#活动性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65167, encryptionId=2d996516e7c, topicName=活动性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596833562866, createdName=楚秀娟, createdTime=Sun Sep 06 03:40:00 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068127, encodeId=b4d1206812e18, content=<a href='/topic/show?id=bc1616639f0' target=_blank style='color:#2F92EE;'>#Spot#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16639, encryptionId=bc1616639f0, topicName=Spot)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Fri Nov 27 08:40:00 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849824, encodeId=4230184982427, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Sep 23 01:40:00 CST 2020, time=2020-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1254318, encodeId=6850125431876, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Mon Dec 23 03:40:00 CST 2019, time=2019-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364554, encodeId=1cd3136455495, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Mon Dec 23 03:40:00 CST 2019, time=2019-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519047, encodeId=a47a151904e31, content=<a href='/topic/show?id=ba989452f5' target=_blank style='color:#2F92EE;'>#IFN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9452, encryptionId=ba989452f5, topicName=IFN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b711235060, createdName=bugit, createdTime=Mon Dec 23 03:40:00 CST 2019, time=2019-12-23, status=1, ipAttribution=)]
    2019-12-23 bugit

    #IFN#

    0