NAT COMMUN:生活方式影响老年人大脑结构

2019-02-10 海北 MedSci原创

最近,在549名老年人构成的人群队列中,研究人员探究了四个生活方式变量-酒精消费,吸烟,身体活动,和社会融合-对大脑结构和功能连接的综合和单独贡献。

生活方式有助于产生老年大脑的个体间差异,但之前的研究主要关注单一生活方式变量的影响。

最近,在549名老年人构成的人群队列中,研究人员探究了四个生活方式变量-酒精消费,吸烟,身体活动,和社会融合-对大脑结构和功能连接的综合和单独贡献。

综合生活方式风险评分与左前运动前和右前额叶皮层的萎缩减少,以及与感觉运动和前额叶皮层的更高功能连接相关。虽然结构差异是由酒精消费,身体活动和社会融合驱动的,但吸烟会带来更高的功能连通性。

这些结果表明,组合差异贡献的生活方式变量可能超过其各部分的总和。这些差异通常不被调整遗传风险,抑郁症状或教育来改变。这强调了日常习惯对大脑健康的重要性。


原始出处:

Nora Bittner et al. Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults. Nature Communication, 2019; doi: https://doi.org/10.1038/s41467-019-08500-x


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    2019-10-27 liuli5079
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    2019-08-03 liye789132251
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    2019-02-12 wmr116

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