Sci Rep:幽门螺杆菌感染与颈动脉内膜中层厚度增加无关

2018-09-25 MedSci MedSci原创

幽门螺杆菌感染与很多因素有关,本项研究的目的是确定在横断面观察研究中Hp感染与颈动脉内膜中层厚度(CIMT)之间是否存在独立关联。

背景及目的
幽门螺杆菌感染与很多因素有关,本项研究的目的是确定在横断面观察研究中Hp感染与颈动脉内膜中层厚度(CIMT)之间是否存在独立关联。

方法:
研究人员对13770名受试者采用了13C-尿素呼气试验(13C-UBT)和CIMT超声测量,同时记录了传统的动脉粥样硬化危险因素。与Hp阴性组(29.7%)相比,Hp阳性组(28.6%)中CIMT升高的比例无显着差异(p = 0.164)。HP感染率在增加的CIMT(38.4%)和未增加的CIMT(39.7%)患者之间没有显着差异。然而,所有传统的动脉粥样硬化危险因素包括年龄,性别,BMI,腰围,总胆固醇,低密度脂蛋白胆固醇,极低密度脂蛋白胆固醇,高密度脂蛋白胆固醇,甘油三酯,游离脂肪酸,同型半胱氨酸,收缩压和舒张压,空腹血浆葡萄糖和C反应蛋白在增加的CIMT和未增加的CIMT参与者之间是不同的(P<0.05)。CIMT厚度增加与Hp感染的风险并无显着相关性(OR 0.948;95%CI 0.879-1.022,P=0.164)。

结论
本项研究未发现CIMT与HP感染之间存在明显关联。

原始出处:

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    2019-08-18 kcb069
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    2018-10-06 121832a9m88暂无昵称

    学习了

    0

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