NEJM:纽约地区儿童多系统炎症综合征风险与新冠肺炎疫情

2020-07-02 MedSci原创 MedSci原创

纽约州儿童多系统炎症综合征的出现与SARS-CoV-2的广泛传播相关,其临床表现为皮肤、皮肤粘膜和胃肠道炎症性综合征与心脏功能不全

纽约是全美新冠肺炎的重灾区,近日研究人员就纽约地区儿童多系统炎症综合征(MIS-C)发病率与2019年冠状病毒病之间的相关性进行了考察。
 
研究人员收集了纽约州医院报告的潜在MIS-C病例,包括川崎病,中毒性休克综合症,心肌炎,以及21岁以下住院病人。 研究人员上述数据进行了描述性分析,总结了2020年3月1日至5月10日期间,符合病例定义的MIS-C患者的临床表现、并发症和预后。
 
截至2020年5月10日,共报告191例潜在病例,其中95例确诊,均为新冠肺炎感染者,4例为疑似MIS-C。患者中53例(54%)为男性,31例为黑人,31例(36%)为西班牙裔。31例(31%)患者年龄在0至5岁之间,42名(42%)年龄在6至12岁之间,26名(26%)年龄在13至20岁之间。均表现为主观发热或畏寒,97%有心动过速,80%有胃肠道症状,60%有皮疹,56%有结膜注射,27%有粘膜改变。分别有100%、91%和71%的患者C反应蛋白、d-二聚体和肌钙蛋白水平升高。62%的患者接受了加压素治疗,53%的患者有心肌炎的证据,80%的患者进入重症监护室,2人死亡。平均住院时间为6天。
 
研究认为,纽约州儿童多系统炎症综合征的出现与SARS-CoV-2的广泛传播相关,其临床表现为皮肤、皮肤粘膜和胃肠道炎症性综合征与心脏功能不全。
 
原始出处:
 
Elizabeth M. Dufort et al. Multisystem Inflammatory Syndrome in Children in New York State. N Engl J Med, June 29, 2020.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1431872, encodeId=9a6c14318e26f, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Jul 04 10:05:12 CST 2020, time=2020-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028245, encodeId=ee0410282450d, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Thu Jul 02 22:05:12 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035334, encodeId=725c10353340a, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jul 02 22:05:12 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=800948, encodeId=8ae680094883, content=<a href='/topic/show?id=cfae433e3a4' target=_blank style='color:#2F92EE;'>#多系统炎症综合征#</a>川崎样病, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43373, encryptionId=cfae433e3a4, topicName=多系统炎症综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/02/28/889a1910ded7780f3c049b354f1648b7.jpg, createdBy=2a791737770, createdName=mswert122, createdTime=Thu Jul 02 19:30:42 CST 2020, time=2020-07-02, status=1, ipAttribution=)]
    2020-07-02 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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    2020-07-02 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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    2020-07-02 mswert122

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