Sci Signal：脂肪肝治疗的新靶点BTG1基因被发现

2016-05-29 新华社新华社

中国研究人员最近发现，一种叫BTG1的基因能够帮助小鼠预防脂肪肝，这为治疗脂肪肝提供了新思路。这项研究由中国科学院上海生命科学研究院营养科学研究所的郭非凡教授领导完成，论文发表在新一期美国《科学·信号传导》杂志上。据郭非凡介绍，BTG1基因广泛分布于哺乳动物的各个组织，参与调节一些疾病的发病过程，比如多发性硬化、乳腺癌、前列腺癌等。此前已有研究显示，BTG1基因的表达在肝癌患者的肝脏中

中国研究人员最近发现，一种叫BTG1的基因能够帮助小鼠预防脂肪肝，这为治疗脂肪肝提供了新思路。

这项研究由中国科学院上海生命科学研究院营养科学研究所的郭非凡教授领导完成，论文发表在新一期美国《科学·信号传导》杂志上。

据郭非凡介绍，BTG1基因广泛分布于哺乳动物的各个组织，参与调节一些疾病的发病过程，比如多发性硬化、乳腺癌、前列腺癌等。此前已有研究显示，BTG1基因的表达在肝癌患者的肝脏中显著降低，而肝癌的发生与脂肪肝的进一步发展有关，这就暗示着BTG1基因和脂肪肝关联的可能性。

新研究发现，常用的脂肪肝模型——瘦素受体突变小鼠的肝脏中BTG1基因的表达显著下降。如果给这种小鼠注射BTG1基因，可以缓解其脂肪肝。与此相反，敲除野生小鼠的BTG1基因则可以诱导其出现脂肪肝。

郭非凡说，近年来，非酒精性脂肪肝已迅速跃升为一种常见肝病，并与肥胖、2型糖尿病等代谢综合征密切相关。他们的研究阐明了BTG1基因的相关生理功能，为了解脂肪肝的发病机制及治疗提供了新思路。

原始出处：

Xiao F, Deng J, Guo Y, Niu Y, Yuan F, Yu J, Chen S, Guo F. BTG1 ameliorates liver steatosis by decreasing stearoyl-CoA desaturase 1 (SCD1) abundance and altering hepatic lipid metabolism. Sci Signal. 2016 May 17;9(428):ra50. doi: 10.1126/scisignal.aad8581.

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2016-10-16 智者为医08

#Signal#

36 0
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2016-09-19 楚秀娟

#Sign#

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2016-12-15 zhu_jun9837

#BTG1#

39 0
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2016-06-03 忠诚向上

好好学习

126 0
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2016-05-31 忠诚向上

多学学！

128 0
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2016-05-31 lsndxfj

#新靶点#

41 0
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2016-05-30 老段

了解一下

132 0
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2016-05-30 milkshark

不错的内容

139 0
[GetPortalCommentsPageByObjectIdResponse(id=1793965, encodeId=aee61e9396589, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Oct 16 16:21:00 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036133, encodeId=837b2036133bb, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Mon Sep 19 17:21:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2048270, encodeId=e3e720482e09b, content=<a href='/topic/show?id=a85c3e69fb' target=_blank style='color:#2F92EE;'>#BTG1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3769, encryptionId=a85c3e69fb, topicName=BTG1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Thu Dec 15 14:21:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88345, encodeId=630a8834557, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Jun 03 08:15:00 CST 2016, time=2016-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87693, encodeId=ab418e6939e, content=多学学！, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue May 31 05:38:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288167, encodeId=dd27128816ee1, content=<a href='/topic/show?id=f10658e342d' target=_blank style='color:#2F92EE;'>#新靶点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58734, encryptionId=f10658e342d, topicName=新靶点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Tue May 31 02:21:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87487, encodeId=57be8e48766, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Mon May 30 06:51:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87462, encodeId=84848e4625a, content=不错的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon May 30 06:39:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87463, encodeId=80818e4637c, content=不错的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon May 30 06:39:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87444, encodeId=eeeb8e444e6, content=内容新，？, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun May 29 22:05:00 CST 2016, time=2016-05-29, status=1, ipAttribution=)]
2016-05-30 milkshark

不错的内容

142 0
[GetPortalCommentsPageByObjectIdResponse(id=1793965, encodeId=aee61e9396589, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Oct 16 16:21:00 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036133, encodeId=837b2036133bb, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Mon Sep 19 17:21:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2048270, encodeId=e3e720482e09b, content=<a href='/topic/show?id=a85c3e69fb' target=_blank style='color:#2F92EE;'>#BTG1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3769, encryptionId=a85c3e69fb, topicName=BTG1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Thu Dec 15 14:21:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88345, encodeId=630a8834557, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Jun 03 08:15:00 CST 2016, time=2016-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87693, encodeId=ab418e6939e, content=多学学！, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue May 31 05:38:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288167, encodeId=dd27128816ee1, content=<a href='/topic/show?id=f10658e342d' target=_blank style='color:#2F92EE;'>#新靶点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58734, encryptionId=f10658e342d, topicName=新靶点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Tue May 31 02:21:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87487, encodeId=57be8e48766, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Mon May 30 06:51:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87462, encodeId=84848e4625a, content=不错的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon May 30 06:39:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87463, encodeId=80818e4637c, content=不错的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon May 30 06:39:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87444, encodeId=eeeb8e444e6, content=内容新，？, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun May 29 22:05:00 CST 2016, time=2016-05-29, status=1, ipAttribution=)]
2016-05-29 忠诚向上

内容新，？

91 0

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