Sci Rep:协和研究称,我国高尿酸血症患病率为13%

2017-07-19 朱柳媛 中国循环杂志

北京协和医院学者开展的一项全国性研究表明,我国人群中高尿酸血症患病率为13%,男性中高达18.5%,明显高于女性(8.0%)。

北京协和医院学者开展的一项全国性研究表明,我国人群中高尿酸血症患病率为13%,男性中高达18.5%,明显高于女性(8.0%)。

在65岁以下男性中,高尿酸血症患病率随年龄增长而降低,到65岁以上才又升高。

而在≥35岁的女性中,高尿酸血症患病率随年龄增长一直升高。研究者认为,这可能与性激素的相互作用有关。

就地域来说,南方地区和农村的高尿酸血症患病率高于北方地区和城市。

按民族区分,回族中高尿酸血症患病率最低,男性中为8%,女性中仅3.8%。

研究者还发现,高尿酸血症患者常合并多个心血管病危险因素。高尿酸血症患者中2~3个心血管病危险因素的合并率为30.5%~32.3%,而在血尿酸水平正常的人群中,合并率为14.5%~22.5%。

多因素分析显示,高尿酸血症的男士合并3个及以上心血管病危险因素的可能性增加2倍,而女士风险更高,增加3倍。

研究者指出,该研究表明,尿酸与心血管病有关,尤其在心血管病高危人群和女性中,因此,未来的研究应进一步探讨降尿酸治疗对心血管病的防治作用。

该研究于2007-2011年纳入全国有代表性的22 983例成年受试者。高尿酸血症定义为:血尿酸水平男性≥416 mmol/L,女性≥357 mmol/L。

原始出处:
Wu J, Qiu L, Cheng XQ, et al. Hyperuricemia and clustering of cardiovascular risk factors in the Chinese adult population. Sci Rep. 2017 Jul 14;7(1):5456.

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    2017-07-21 明天会更好!

    学习过了,谢谢分享!

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    2017-07-20 李东泽

    很好,不错,以后会多学习

    0

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    2017-07-19 1ddf0692m34(暂无匿称)

    学习了,涨知识

    0

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    2017-07-19 Y—xianghai

    学习了新知识

    0

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我们的研究结果表明,在患有2型糖尿病中国男性和绝经后女性,高尿酸血症,高水平的FEUA,男性,年龄和白蛋白尿是SRC发展的独立危险因素。一半过量产生高尿酸血症患者有SRC。因此,高尿酸血症和/或高FEUA的2型糖尿病患者有SRC的风险。没有研究评估服用尿酸排泄剂的高尿酸血症或痛风患者的SRC患病率。需要进行前瞻性研究来探讨尿酸排泄物是否会影响SRC的发生。

Arthritis Rheumatol:痛风,如何用药效果更好?

在324例腹痛患者的III期临床试验中,与芬布斯他汀联合使用的药物维生素在降低尿酸血症水平方面比单独使用氟比斯坦更好。超过12个月的实验观察之后,联合药物组合组的使用患者中,已经有显着多的患者达到目标水平的尿酸盐,这比单用芬布斯他汀组效果更明显。

Hypertension:不伴合并症的无症状高尿酸血症可以预测心脏代谢性疾病!

总之,无症状高尿酸血症再无合并症的个体中发生心脏代谢疾病的风险显著。

Am J Kidney Dis:无症状高尿酸血症与肾结石有啥关系?

在这项大型队列研究中,健康男性血尿酸水平升高与肾结石发生风险增加中度并且独立相关,而且以剂量依赖的方式。