Clinical Gastroenterology H:慢性腹泻和便秘在抑郁症患者中更常见

2019-11-28 不详 MedSci原创

抑郁症与胃肠道疾病高度并存。本项研究旨在研究抑郁症与排便习惯之间的关系。

背景和目标
抑郁症与肠道疾病高度并存。本项研究旨在研究抑郁症与排便习惯之间的关系。

方法
研究人员使用NHANES(2009-2010)的数据库确定了495位抑郁症患者和4709位非抑郁症成年人,并然所有受试者填写了《肠道健康调查表》。抑郁症的诊断由专家进行鉴定。研究人员使用多变量分析来控制临床和人口统计学变量,以评估情绪与排便习惯之间的关系。

结果
在本项研究中有24.6%的抑郁者和12.6%的非抑郁者报告了排便习惯紊乱。抑郁症患者的慢性腹泻发生率(15.53%; 95%CI,11.34%–20.90%)明显高于非抑郁症患者(6.05%; 95%CI,5.24%–6.98%;P=.0001)。抑郁症患者的慢性便秘(9.10%; 95%CI,7.02%–11.69%)也比非抑郁症患者(6.55%; 95%CI,5.55%–7.70%;P = 0.003)更常见。慢性腹泻患者(4.9±5.8)和慢性便秘患者(4.4±4.93)的平均抑郁评分显着高于正常肠习惯患者的平均抑郁评分(3.2±4.6)(P<.001)。中度和重度抑郁与慢性腹泻显着相关,但与慢性便秘无关。只有轻度抑郁与慢性便秘显着相关。

结论
本项研究发现患有抑郁症的人比没有抑郁症的人有更多的慢性腹泻和便秘。慢性腹泻与抑郁症的关系更大。

原始出处:
Sarah Ballou,et al.Chronic Diarrhea and Constipation Are More Common in Depressed Individuals. Clinical Gastroenterology H.2019.

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    2019-12-19 许安
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    2019-11-30 zll0628