Stroke:无症状脑梗死(SBI)是未来发生卒中的强有力预测因素

2016-02-20 MedSci MedSci原创

无症状脑梗死(SBI)的磁共振成像已被提出可用于将来对症状性脑卒中亚临床风险标志物。研究人员进行了一项系统回顾和荟萃分析总结了磁共振成像定义SBI和未来中风的风险之间的关联。研究人员检索了医学文献,以确定涉及SBI成人磁共振成像的队列研究,并且随后进行了临床定义为卒中事件的检测。研究数据和质量评估记录一式两份,提取的有分歧的数据通过第三个读者解决。磁共振成像检测的SBI和未来的症状性卒中之间的关联

无症状脑梗死(SBI)的磁共振成像已被提出可用于将来对症状性脑卒中亚临床风险标志物。研究人员进行了一项系统回顾和荟萃分析总结了磁共振成像定义SBI和未来中风的风险之间的关联。

研究人员检索了医学文献,以确定涉及SBI成人磁共振成像的队列研究,并且随后进行了临床定义为卒中事件的检测。研究数据和质量评估记录一式两份,提取的有分歧的数据通过第三个读者解决。磁共振成像检测的SBI和未来的症状性卒中之间的关联强度是由风险比率计算得到的。

该荟萃分析共包括13项研究(14764例患者),平均随访范围为25.7至174个月。SBI预测卒中的发生随机效应原始的相对危险度为2.94(95%置信区间,2.24-3.86,P<0.001,Q=39.65,P<0.001)。在10427例患者的8项研究中,调整了心血管危险因素后,SBI是卒中发生的独立预测因素(危险比2.08[95%置信区间,1.69-2.56; P<0.001]; Q=8.99,P=0.25)。在亚组分析中,汇集了来自大型群组研究的9483名无中风的参与者,约18%的参与者存在SBI,仍是未来发生卒中的强有力的预测因素(危险比为2.06[95%置信区间,1.64-2.59];P<0.01)。

5名非卒中老年人中约有1人存在SBI,且未来中风的危险增加2倍。未来的研究对于临床影像学无法识别大脑明显梗死的患者进行深入卒中风险评估和重症防治措施是必要的。

原始出处:

Gupta A,Giambrone AE,Gialdini G,et al.Silent Brain Infarction and Risk of Future Stroke,Stroke,2016.2.18

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    2016-02-22 karmond
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createdName=忠诚向上, createdTime=Sat Feb 20 22:09:00 CST 2016, time=2016-02-20, status=1, ipAttribution=)]
  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Sun Feb 21 03:47:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65010, encodeId=485b650109e, content=不详, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sun Feb 21 00:46:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=64987, encodeId=82446498e8f, content=多学学, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Feb 20 22:09:00 CST 2016, time=2016-02-20, status=1, ipAttribution=)]
    2016-02-21 医科小蚂蚁

    所以?

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Sun Feb 21 03:47:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65010, encodeId=485b650109e, content=不详, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sun Feb 21 00:46:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=64987, encodeId=82446498e8f, content=多学学, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Feb 20 22:09:00 CST 2016, time=2016-02-20, status=1, ipAttribution=)]
    2016-02-21 inter158

    为了不表现出症状的病做昂贵的核磁是不是只能处于理想研究状态!?

    0

  7. 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createdName=忠诚向上, createdTime=Sat Feb 20 22:09:00 CST 2016, time=2016-02-20, status=1, ipAttribution=)]
    2016-02-21 1de07360m07(暂无匿称)

    学习了解

    0

  8. 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encryptionId=4bbe5902ed2, topicName=无症状)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20180429/70baad2aa5a046c5aa2914d262de7d37.jpg, createdBy=bd077990475, createdName=12498da4m34(暂无昵称), createdTime=Mon Feb 22 11:23:00 CST 2016, time=2016-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65070, encodeId=2dee650e04f, content=所以?, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160221/IMG56C96B2E7EA869819.jpg, createdBy=101d1672933, createdName=医科小蚂蚁, createdTime=Sun Feb 21 15:45:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65053, encodeId=70e365053cb, content=为了不表现出症状的病做昂贵的核磁是不是只能处于理想研究状态!?, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, 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createdName=忠诚向上, createdTime=Sat Feb 20 22:09:00 CST 2016, time=2016-02-20, status=1, ipAttribution=)]
    2016-02-21 zwjnj2

    学习了谢谢小编

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Sun Feb 21 13:41:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65020, encodeId=5bf86502040, content=学习了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3bd31668701, createdName=1de07360m07(暂无匿称), createdTime=Sun Feb 21 08:27:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65012, encodeId=21a365012e4, content=学习了谢谢小编, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Sun Feb 21 03:47:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65010, encodeId=485b650109e, content=不详, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sun Feb 21 00:46:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=64987, encodeId=82446498e8f, content=多学学, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Feb 20 22:09:00 CST 2016, time=2016-02-20, status=1, ipAttribution=)]
    2016-02-21 医者仁心5538

    不详

    0

  10. 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createdName=忠诚向上, createdTime=Sat Feb 20 22:09:00 CST 2016, time=2016-02-20, status=1, ipAttribution=)]
    2016-02-20 忠诚向上

    多学学

    0