JACC:流速会影响主动脉瓣面积对AS患者的预测价值

2020-04-20 MedSci原创 MedSci原创

主动脉瓣面积(AVA)≤1.0cm2是严重主动脉瓣狭窄(AS)的特征。在低跨瓣流量时,AVA可能被低估。然而,流速对AVA≤1.0cm2的预测价值的影响尚不清楚,也未纳入评估。本研究的目的

主动脉瓣面积(AVA)≤1.0cm2是严重主动脉瓣狭窄(AS)的特征。在低跨瓣流量时,AVA可能被低估。然而,流速对AVA≤1.0cm2的预测价值的影响尚不清楚,也未纳入评估。本研究的目的旨在评估流速对AS患者AVA预测价值的影响。

本研究纳入分析了1131名中重度AS患者,发现流速对AVA的预测价值有明显的影响,如果在低于中位数的流速(≤242毫升/秒)下测量AVA,AVA≤1.0平方厘米对死亡率没有预测作用(p=0.15)。相反,如果在高于中位数的流速(>242毫升/秒)下测量AVA,AVA≤1.0平方厘米对死亡率有明显的预测作用(p = 0.003)。研究结果与年龄、性别和外科/经导管主动脉瓣置换术、合并症、药物治疗和超声心动图特征的多变量调整无关。预测阈值的最佳流速截止值为210ml/s。

研究结果显示,对于中重度AS患者,流速对主动脉瓣面积的预测价值有明显影响,低流速下AVA不是一个良好的预后预测因子。

原始出处:

Mayooran N et al.Transvalvular Flow Rate Determines Prognostic Value of Aortic Valve Area in Aortic Stenosis.JACC.2020 Apr.

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    2021-01-04 hbwxf
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