J Periodontol: HLA-B57.01与艾滋病人牙周健康之间的关系

2018-08-19 MedSci MedSci原创

评估HLA-B57.01(人类白细胞抗原)与艾滋病病毒感染者(PLWHIV)慢性牙周炎临床参数之间的关系。

评估HLA-B57.01(人类白细胞抗原)与艾滋病病毒感染者(PLWHIV)慢性牙周炎临床参数之间的关系。

方法:所有患者均于2014年4月和2015年7月期间在法兰克福大学医院的HIVCENTER招募。牙周检查包括牙周筛查指数(PSI),牙龈指数(GI),探诊出血(BOP),牙周探诊深度(PD),临床附着水平(CAL)和DMF-T评分(龋坏,缺失,充填)。在多变量分析中评估牙周炎,HLA系统和PLWHIV中的其他危险因素之间的关联。

结果:招募了100名艾滋病病毒感染者。 45名患者是初发的,意味着这些患者以前从未服用抗逆转录病毒(ARV)药物,55名患者接受过联合抗逆转录病毒治疗(cART)治疗。 19名患者呈现HLA-B 57.01阳性。作为HLA-B 57.01携带者的PLWHIV具有显着较低的PSI评分(3级或更高; 0/19 [0%] vs 16/41 [39%] vs 17/40 [42%]; p = <0.001) ,GI评分(2级或更高; 0/19 [0%] vs 19/41 [46%] vs 28/40 [70%]; p = <0.001)和BOP评分(2/19 [1%]与未接受cART的初发PLWHIV和PLWHIV相比,38/41 [92%] vs 40/40 [100%]; p = <0.001),这两者都不是HLA-B 57.01的携带者。较低的PSI,GI和BOP评分值与牙周健康的改善有关。通过PSI评分(OR = 0.006,95%置信区间(CI)= 0.001至0.026),GI评分(OR),HLA-B 57.01患者牙周炎的校正比值比(OR)降低= 0.018,95%置信区间(CI)= 0.003至0.104)和BOP评分(OR = 0.003,95%置信区间(CI)= <0.001至0.011)。

HLA-B 57.01是PLWHIV中广泛性牙周炎的独立抗性指标

原始出处:

Gundolf Schuettfort, et al. HLA‐B57.01 shields people living with HIV for significantly better periodontal health. Journal of Periodontology. 2018 August. doi:10.1002/JPER.17-0532

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    2018-10-29 feather89
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    2018-08-21 marongnuan

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J Periodontol: hla-b57.01可以指示艾滋病人的牙周健康?

本实验旨在评估患有慢性牙周炎的HIV感染者HLA-B57.01(人类白细胞抗原)与牙周临床参数之间的关系。