European Radiology:热消融在肝细胞癌治疗中的价值

2022-05-01 shaosai MedSci原创

本研究发现,TA对原发性和复发性HCC都是一种有效的治疗方式。虽然许多患者在随访过程中出现复发,但本研究证明,大多数患者可以通过重复TA进行治疗以缓解病情。

众所周知肝细胞癌(HCC)全球范围内的发病率和死亡率的居高不下。根据BCLC分类法,通常只有极早期(单个病变,<2厘米)和早期HCC(最多三个病变,每个病变<3厘米)是可以根治的根治性治疗方案包括热消融(TA,包括微波消融和射频消融)、肝切除(HR)和原位肝移植(OLTx)。

对于早期和极早期HCC的最佳治疗策略仍有争议。已有证据表明,TA可以使原发性HCC的局部区域得到良好的控制。然而,目前缺乏关于复发性HCC进行重复TA疗效的数据。近日,发表在European Radiology杂志的一项研究评估了复发性HCC进行重复TA的疗效,为HCC患者治疗术式的准确选择提供了有价值的参考依据。 

本研究对一家三级肝胆科中心的HCC患者的干预措施进行了评估。研究的结果是初诊TA后及其重复干预后的复发率、无法治疗的复发的出现初诊和重复TA后的OS和DSS以及TA后的并发症。在混杂因素匹配的队列中,比较了有无打算进行OLTx的TA后的OS和DSS。 

TA后,100名患者(56-8%)出现了复发性HCC,其中76名(76-0%)接受了多达4次的重复干预。在随访期间,76-7%的患者未出现过无法重复TA或OLTx的复发。初次TA和重复TA后的OS是相当的。在匹配的队列中,进行或不进行OLTx的TA后,OS和DSS是相当的。 


 HCC初级热消融(TA)后患者的具体治疗路径。显示了后续再干预后的顺序和结果

本研究发现,TA对原发性和复发性HCC都是一种有效的治疗方式。虽然许多患者在随访过程中出现复发,但本研究证明,大多数患者可以通过重复TA进行治疗以缓解病情。

原文出处:

Christiaan M C Serbanescu-Kele Apor de Zalán,Simeon J S Ruiter,Aad P van den Berg,et al.Outcomes after primary and repeat thermal ablation of hepatocellular carcinoma with or without liver transplantation.DOI:10.1007/s00330-021-08515-3

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createdName=qingting, createdTime=Tue May 10 01:12:03 CST 2022, time=2022-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634252, encodeId=f7e3163425258, content=<a href='/topic/show?id=5abf6e2114f' target=_blank style='color:#2F92EE;'>#热消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67211, encryptionId=5abf6e2114f, topicName=热消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=04a722134767, createdName=花花1373, createdTime=Sat Apr 08 07:12:03 CST 2023, time=2023-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863665, encodeId=801d1863665a7, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Sun Apr 16 05:12:03 CST 2023, time=2023-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421898, encodeId=66f514218984f, content=<a href='/topic/show?id=4bc865819d2' target=_blank style='color:#2F92EE;'>#消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65819, encryptionId=4bc865819d2, topicName=消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a193676008, createdName=xiangyuzhou972, createdTime=Tue May 03 06:12:03 CST 2022, time=2022-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216230, encodeId=c16d12162309e, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Mon May 02 07:41:30 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216225, encodeId=523e12162253e, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Mon May 02 07:17:31 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216141, encodeId=7903121614107, content=***,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun May 01 19:30:54 CST 2022, time=2022-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216110, encodeId=199e121611063, content=<a href='/topic/show?id=735a81364b7' target=_blank style='color:#2F92EE;'>#肝细胞癌#</a>所有消融、介入的最大问题在于,如何彻底和干净??还是应该消融减轻肿瘤负荷,然后再加上<a href='/topic/show?id=daf52906537' target=_blank style='color:#2F92EE;'>#免疫治疗#</a>+<a href='/topic/show?id=4399103e93a7' target=_blank style='color:#2F92EE;'>#抗血管新生#</a>治疗,应该会更好吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81364, encryptionId=735a81364b7, topicName=肝细胞癌), TopicDto(id=29065, encryptionId=daf52906537, topicName=免疫治疗), TopicDto(id=103793, encryptionId=4399103e93a7, topicName=抗血管新生)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun May 01 18:55:48 CST 2022, time=2022-05-01, status=1, ipAttribution=)]
    2023-04-16 xjy02
  5. [GetPortalCommentsPageByObjectIdResponse(id=1729532, encodeId=1fda1e2953276, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Aug 17 11:12:03 CST 2022, time=2022-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1979327, encodeId=e25119e932762, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue May 10 01:12:03 CST 2022, time=2022-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634252, encodeId=f7e3163425258, content=<a href='/topic/show?id=5abf6e2114f' target=_blank style='color:#2F92EE;'>#热消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67211, encryptionId=5abf6e2114f, topicName=热消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=04a722134767, createdName=花花1373, createdTime=Sat Apr 08 07:12:03 CST 2023, time=2023-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863665, encodeId=801d1863665a7, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Sun Apr 16 05:12:03 CST 2023, time=2023-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421898, encodeId=66f514218984f, content=<a href='/topic/show?id=4bc865819d2' target=_blank style='color:#2F92EE;'>#消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65819, encryptionId=4bc865819d2, topicName=消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a193676008, createdName=xiangyuzhou972, createdTime=Tue May 03 06:12:03 CST 2022, time=2022-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216230, encodeId=c16d12162309e, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Mon May 02 07:41:30 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216225, encodeId=523e12162253e, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Mon May 02 07:17:31 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216141, encodeId=7903121614107, content=***,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun May 01 19:30:54 CST 2022, time=2022-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216110, encodeId=199e121611063, content=<a href='/topic/show?id=735a81364b7' target=_blank style='color:#2F92EE;'>#肝细胞癌#</a>所有消融、介入的最大问题在于,如何彻底和干净??还是应该消融减轻肿瘤负荷,然后再加上<a href='/topic/show?id=daf52906537' target=_blank style='color:#2F92EE;'>#免疫治疗#</a>+<a href='/topic/show?id=4399103e93a7' target=_blank style='color:#2F92EE;'>#抗血管新生#</a>治疗,应该会更好吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81364, encryptionId=735a81364b7, topicName=肝细胞癌), TopicDto(id=29065, encryptionId=daf52906537, topicName=免疫治疗), TopicDto(id=103793, encryptionId=4399103e93a7, topicName=抗血管新生)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun May 01 18:55:48 CST 2022, time=2022-05-01, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1729532, encodeId=1fda1e2953276, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Aug 17 11:12:03 CST 2022, time=2022-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1979327, encodeId=e25119e932762, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue May 10 01:12:03 CST 2022, time=2022-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634252, encodeId=f7e3163425258, content=<a href='/topic/show?id=5abf6e2114f' target=_blank style='color:#2F92EE;'>#热消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67211, encryptionId=5abf6e2114f, topicName=热消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=04a722134767, createdName=花花1373, createdTime=Sat Apr 08 07:12:03 CST 2023, time=2023-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863665, encodeId=801d1863665a7, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Sun Apr 16 05:12:03 CST 2023, time=2023-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421898, encodeId=66f514218984f, content=<a href='/topic/show?id=4bc865819d2' target=_blank style='color:#2F92EE;'>#消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65819, encryptionId=4bc865819d2, topicName=消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a193676008, createdName=xiangyuzhou972, createdTime=Tue May 03 06:12:03 CST 2022, time=2022-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216230, encodeId=c16d12162309e, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Mon May 02 07:41:30 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216225, encodeId=523e12162253e, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Mon May 02 07:17:31 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216141, encodeId=7903121614107, content=***,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun May 01 19:30:54 CST 2022, time=2022-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216110, encodeId=199e121611063, content=<a href='/topic/show?id=735a81364b7' target=_blank style='color:#2F92EE;'>#肝细胞癌#</a>所有消融、介入的最大问题在于,如何彻底和干净??还是应该消融减轻肿瘤负荷,然后再加上<a href='/topic/show?id=daf52906537' target=_blank style='color:#2F92EE;'>#免疫治疗#</a>+<a href='/topic/show?id=4399103e93a7' target=_blank style='color:#2F92EE;'>#抗血管新生#</a>治疗,应该会更好吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81364, encryptionId=735a81364b7, topicName=肝细胞癌), TopicDto(id=29065, encryptionId=daf52906537, topicName=免疫治疗), TopicDto(id=103793, encryptionId=4399103e93a7, topicName=抗血管新生)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun May 01 18:55:48 CST 2022, time=2022-05-01, status=1, ipAttribution=)]
    2022-05-02 学医无涯

    了解一下

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1729532, encodeId=1fda1e2953276, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Aug 17 11:12:03 CST 2022, time=2022-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1979327, encodeId=e25119e932762, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, 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encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Sun Apr 16 05:12:03 CST 2023, time=2023-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421898, encodeId=66f514218984f, content=<a href='/topic/show?id=4bc865819d2' target=_blank style='color:#2F92EE;'>#消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65819, encryptionId=4bc865819d2, topicName=消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a193676008, createdName=xiangyuzhou972, createdTime=Tue May 03 06:12:03 CST 2022, time=2022-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216230, encodeId=c16d12162309e, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Mon May 02 07:41:30 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216225, encodeId=523e12162253e, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Mon May 02 07:17:31 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216141, encodeId=7903121614107, content=***,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun May 01 19:30:54 CST 2022, time=2022-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216110, encodeId=199e121611063, content=<a href='/topic/show?id=735a81364b7' target=_blank style='color:#2F92EE;'>#肝细胞癌#</a>所有消融、介入的最大问题在于,如何彻底和干净??还是应该消融减轻肿瘤负荷,然后再加上<a href='/topic/show?id=daf52906537' target=_blank style='color:#2F92EE;'>#免疫治疗#</a>+<a href='/topic/show?id=4399103e93a7' target=_blank style='color:#2F92EE;'>#抗血管新生#</a>治疗,应该会更好吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81364, encryptionId=735a81364b7, topicName=肝细胞癌), TopicDto(id=29065, encryptionId=daf52906537, topicName=免疫治疗), TopicDto(id=103793, encryptionId=4399103e93a7, topicName=抗血管新生)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun May 01 18:55:48 CST 2022, time=2022-05-01, status=1, ipAttribution=)]
    2022-05-02 1064510_1039
  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Mon May 02 07:41:30 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216225, encodeId=523e12162253e, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Mon May 02 07:17:31 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216141, encodeId=7903121614107, content=***,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun May 01 19:30:54 CST 2022, time=2022-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216110, encodeId=199e121611063, content=<a href='/topic/show?id=735a81364b7' target=_blank style='color:#2F92EE;'>#肝细胞癌#</a>所有消融、介入的最大问题在于,如何彻底和干净??还是应该消融减轻肿瘤负荷,然后再加上<a href='/topic/show?id=daf52906537' target=_blank style='color:#2F92EE;'>#免疫治疗#</a>+<a href='/topic/show?id=4399103e93a7' target=_blank style='color:#2F92EE;'>#抗血管新生#</a>治疗,应该会更好吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81364, encryptionId=735a81364b7, topicName=肝细胞癌), TopicDto(id=29065, encryptionId=daf52906537, topicName=免疫治疗), TopicDto(id=103793, encryptionId=4399103e93a7, topicName=抗血管新生)], attachment=null, authenticateStatus=null, 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    2022-05-01 1209e435m98(暂无昵称)

    ***,谢谢分享

    0

  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Mon May 02 07:41:30 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216225, encodeId=523e12162253e, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Mon May 02 07:17:31 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216141, encodeId=7903121614107, content=***,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun May 01 19:30:54 CST 2022, time=2022-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216110, encodeId=199e121611063, content=<a href='/topic/show?id=735a81364b7' target=_blank style='color:#2F92EE;'>#肝细胞癌#</a>所有消融、介入的最大问题在于,如何彻底和干净??还是应该消融减轻肿瘤负荷,然后再加上<a href='/topic/show?id=daf52906537' target=_blank style='color:#2F92EE;'>#免疫治疗#</a>+<a href='/topic/show?id=4399103e93a7' target=_blank style='color:#2F92EE;'>#抗血管新生#</a>治疗,应该会更好吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81364, encryptionId=735a81364b7, topicName=肝细胞癌), TopicDto(id=29065, encryptionId=daf52906537, topicName=免疫治疗), TopicDto(id=103793, encryptionId=4399103e93a7, topicName=抗血管新生)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun May 01 18:55:48 CST 2022, time=2022-05-01, status=1, ipAttribution=)]
    2022-05-01 病毒猎手

    #肝细胞癌#所有消融、介入的最大问题在于,如何彻底和干净??还是应该消融减轻肿瘤负荷,然后再加上#免疫治疗#+#抗血管新生#治疗,应该会更好吧

    0

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