JAMA Neurol:激活干预可延缓轻度认知功能障碍人群病情进展

2018-09-11 zhangfan MedSci原创

研究认为轻度认知功能障碍人群接受行为激活干预可延缓认知和日常功能衰退进程

轻度认知功能障碍(MCI)是正常认知老化和痴呆之间的过渡状态,MCI患者进行性认知衰退的风险增加。近日研究人员考察了为期2年的行为激活干预对MCI黑人群体认知及日常功能衰退的作用。

315名65岁以上健忘性MCI黑人患者参与筛查,其中205人认知正常(65%),59人轻微痴呆(18.7%),221名合格参与者参与分组,其中111人接受旨在增加认知、身体和社会活动的干预(50.2%),110人接受注意力控制辅助治疗(49.8%)。研究的主要终点为霍普金斯语言学习回忆测验分数变化,次要终点为日常功能衰退。

参与者平均年龄75.8岁,女性占79%。行为激活组77人(69.4%),支持治疗组87人(79.1%)进行2年疗效评估。相比于基线,行为激活组参与认知活动的能力和积极性显著优于支持治疗组。行为激活组2年记忆衰退了1.2%,而支持组衰退了9.3%(RR=0.12)。行为激活组患者日常功能保持稳定,而支持组显著下降。

研究认为轻度认知功能障碍人群接受行为激活干预可延缓认知和日常功能衰退进程。

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    2018-09-22 yinhl1978
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