Am J Clin Nutr:补充维生素D可以降低绝经后乳腺癌风险

2015-10-25 Seven L 译 MedSci原创

有研究表明维生素D可以对乳腺癌发生的发生起保护作用,尤其是雌激素受体阳性的肿瘤,不过目前关于该经验性结果的流行病学研究并没有。研究者进行了一项研究探究绝经后乳腺癌风险和现在或过去维生素D补充情况间关系,以及根据更年期激素疗法(MHT)的使用情况进行分层研究。该研究在1995-2008年间从E3N前瞻性队列研究中纳入了 57,403名绝经后妇女,在长达 581,085 人年的随访过程中,发生率248

有研究表明维生素D可以对乳腺癌的发生起保护作用,尤其是雌激素受体阳性的肿瘤,不过目前并没有关于该经验性结果的流行病学研究。

研究者进行了一项研究探究绝经后乳腺癌风险和现在或过去维生素D补充情况间关系,以及根据更年期激素疗法(MHT)的使用情况进行分层研究。

该研究在1995-2008年间从E3N前瞻性队列研究中纳入了 57,403名绝经后妇女,在长达 581,085 人-年的随访过程中,发生了2482例浸润性乳腺癌。研究者根据1995年、2000年、2002年以及2005年的问卷调查,以及自2004年以来药物使用情况,评估参与者维生素D摄入情况。

研究结果显示,对于绝经后乳腺癌,目前补充维生素D可以降低其风险 (HR: 0.82; 95% CI: 0.69, 0.97),但是对于过去补充维生素D并不会起到保护作用 (HR: 1.10; 95% CI: 0.92, 1.31) (P-homogeneity = 0.02)。

更年期激素疗法(MHT)的使用与否,也会对该联系产生影响。对于现在补充维生素D+使用过MHT的人群:HR: 0.74; 95% CI: 0.60, 0.90;现在补充维生素D但没有使用过MHT的人群:HR: 1.13; 95% CI: 0.89, 1.56;P-homogeneity = 0.02。

该观察研究表明。现在维生素D的补充,尤其是每日补充且补钙,可用降低MHT使用人群的绝经后乳腺癌发生风险。

原始出处:


Cadeau , Fournier A, Mesrine S,et al.Interaction between current vitamin D supplementation and menopausal hormone therapy use on breast cancer risk: evidence from the E3N cohort.Am J Clin Nutr. 2015 Oct;102(4):966-73.


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    2016-02-27 sjq027
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    2016-01-13 Lynee劲飞扬

    给力

    0

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    2015-10-31 liusanxin

    维生素反正无大害

    0

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    2015-10-27 zxxiang
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    2015-10-26 lixh1719

    依据还不是很充分

    0

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