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FDA批准STAT3抑制剂WP1066治疗小儿脑癌试验的IND

2020-02-20 Allan MedSci原创

WP1066STAT3FDA小儿脑癌
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WPD是一家临床阶段制药公司，今日宣布，美国FDA批准了STAT3抑制剂WP1066治疗小儿复发性或难治性恶性脑肿瘤的研究性新药（IND）申请，以开展I期临床试验，该试验将在亚特兰大儿童保健中心进行。

WPD是一家临床阶段制药公司，今日宣布，美国FDA批准了STAT3抑制剂WP1066治疗小儿复发性或难治性恶性脑肿瘤的研究性新药（IND）申请，以开展I期临床试验，该试验将在亚特兰大儿童保健中心进行。WP1066能够抑制p-STAT3和其他致癌转录因子，同时还能刺激针对脑肿瘤、胰腺癌和血液系统恶性肿瘤的自然免疫反应。

WPD首席执行官Mariusz Olejniczak表示：“目前正在MD Anderson癌症中心开展WP1066治疗胶质母细胞瘤的临床试验。埃默里大学的临床前研究表明WP1066对髓母细胞瘤细胞系具有显著的抗肿瘤作用，因此我们相信WP1066具有治疗恶性脑肿瘤的潜力”。脑瘤是指脑内异常细胞的形成，定义为任何颅内肿瘤，发生的位置包括了脑本身各种细胞（神经元、胶质细胞、淋巴组织以及血管）、脑神经、脑膜、头骨、脑下垂体以及由其它器官转移的转移性脑瘤。


原始出处：

https://www.firstwordpharma.com/node/1702336?tsid=4

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    2020-10-07 jklm09

    #抑制剂#

    0

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    2020-03-14 ms5353107019656438

    #小儿脑癌#

    0

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    2020-10-26 bugit

    #FDA批准#

    0

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    2020-02-22 李研东

    #STAT3#

    0

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    2020-02-22 ms2694732865965676

    #脑癌#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1852277, encodeId=2e7618522e750, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Wed Oct 07 08:50:00 CST 2020, time=2020-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740182, encodeId=b0661e40182e9, content=<a href='/topic/show?id=f8f54693e4d' target=_blank style='color:#2F92EE;'>#小儿脑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46937, encryptionId=f8f54693e4d, topicName=小儿脑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5b9b34667684, createdName=ms5353107019656438, createdTime=Sat Mar 14 01:50:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1839769, encodeId=fb461839e6962, content=<a href='/topic/show?id=341ae311ea' target=_blank style='color:#2F92EE;'>#FDA批准#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7311, encryptionId=341ae311ea, topicName=FDA批准)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=bugit, createdTime=Mon Oct 26 14:50:00 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348974, encodeId=211c13489e414, content=<a href='/topic/show?id=684f16e52c8' target=_blank style='color:#2F92EE;'>#STAT3#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16752, encryptionId=684f16e52c8, topicName=STAT3)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e7948, createdName=李研东, createdTime=Sat Feb 22 13:50:00 CST 2020, time=2020-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391903, encodeId=b2481391903f3, content=<a href='/topic/show?id=085c8495615' target=_blank style='color:#2F92EE;'>#脑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84956, encryptionId=085c8495615, topicName=脑癌)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Sat Feb 22 13:50:00 CST 2020, time=2020-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469154, encodeId=bddd146915415, content=<a href='/topic/show?id=211f98250b' target=_blank style='color:#2F92EE;'>#IND#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9825, encryptionId=211f98250b, topicName=IND)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16377007930, createdName=xiaogang319, createdTime=Sat Feb 22 13:50:00 CST 2020, time=2020-02-22, status=1, ipAttribution=)]
    2020-02-22 xiaogang319

    #IND#

    0