Bone:在老年男性中维生素D水平与2型糖尿病患病风险之间没有联系

2016-07-12 zhaoshuang 译 MedSci原创

根据近期男性骨质疏松性骨折的相关研究分析,血清25羟维生素D水平与老年男性2型糖尿病事件发生无关。Napoli和同事研究了1939名年龄大于65岁参与the Osteoporotic Fractures in Men (MrOS)的研究美国男性的数据。所有的参与者均进行基线访问,提供了清晨空腹的血液样本,医疗和个人史和完成了食物频率问卷调查,并进行四个周期的随访,随访中参与者提供糖尿病事件的发生情

根据近期男性骨质疏松性骨折的相关研究分析,血清25羟维生素D水平与老年男性2型糖尿病事件发生无关。

Napoli和同事研究了1939名年龄大于65岁参与the Osteoporotic Fractures in Men (MrOS)研究的美国男性的数据。所有的参与者均进行基线访问,提供了清晨空腹的血液样本,医疗和个人史、完成了食物频率问卷调查,并进行四个周期的随访,随访中参与者提供糖尿病事件的发生情况和药物史。队列中平均25-(OH)D水平的为26.1 ng/mL。研究者使用Cox比例风险模型评估维生素D水平与2型糖尿病的发生之间的关系,将25-(OH)D作为一个连续变量和分类变量(分为四分位数)。

在连续变量模型中匹配年龄和部位,研究人员发现对高25-(OH)D对2型糖尿病的发生没有保护作用(HR,0.87;95% CI,0.73-1.04)。潜在的关联在匹配BMI、种族,抽血季节和钙的摄入量后减弱(HR = 1.03;95% CI,0.85-1.25)。

在对维生素D水平进行四分位分层后,研究人员发现在25-(OH)D和2型糖尿病的发生无关联(P >0.2)。

本研究表明在老年男性中维生素D水平与2型糖尿病患病风险之间没有联系,但其相关性的确立仍需要更多的研究。

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    2016-10-25 apoenzyme
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  3. [GetPortalCommentsPageByObjectIdResponse(id=1915142, encodeId=6fdf191514209, content=<a href='/topic/show?id=05343619cf' target=_blank style='color:#2F92EE;'>#Bone#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3619, encryptionId=05343619cf, topicName=Bone)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Tue Oct 25 20:07:00 CST 2016, time=2016-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897799, encodeId=4ac5189e799ca, content=<a href='/topic/show?id=a3b080193fe' target=_blank style='color:#2F92EE;'>#老年男性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80193, encryptionId=a3b080193fe, topicName=老年男性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Mon Mar 13 22:07:00 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=132016, encodeId=514e1320169e, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 21 08:14:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129390, encodeId=80b3129390a0, content=不错哦,会学到很多,喜欢梅斯医学文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Sep 17 11:41:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125677, encodeId=16941256e780, content=不断学习新知识充实自己才能做到与时俱进, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 20:06:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=113301, encodeId=aaf81133019e, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Wed Sep 07 17:31:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107352, encodeId=d5d110e352e2, content=好文,值得学习,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 30 11:09:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281741, encodeId=53091281e4159, content=<a href='/topic/show?id=ef315299070' target=_blank style='color:#2F92EE;'>#患病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52990, encryptionId=ef315299070, topicName=患病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Thu Jul 14 04:07:00 CST 2016, time=2016-07-14, status=1, ipAttribution=)]
    2016-09-21 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

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    2016-09-17 1e10c84am36(暂无匿称)

    不错哦,会学到很多,喜欢梅斯医学文章

    0

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    2016-09-13 舒心和人

    不断学习新知识充实自己才能做到与时俱进

    0

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    2016-09-07 李东泽

    很好,不错,以后会多学习

    0

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    2016-08-30 ylzr123

    好文,值得学习,赞!

    0

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