CCI:运动训练对桡动脉导管术后血管功能有益

2012-10-09 Circ Cardiovasc Inte Circ Cardiovasc Inte

  来自英国的一项前瞻性研究表明,桡动脉导管术与动脉内皮剥脱相关,可减弱桡动脉的低血流介导的血管收缩(L-FMC),表明L-FMC的内皮依赖性。此外,该研究首次报道了运动训练对桡动脉血管扩张和括约肌功能的有益影响。研究于2012年9月25日在线发表于《循环﹒介入》(Circ Interventions)杂志。   桡动脉导管术与内皮剥脱和血管舒张功能受损相关联,而导管术后的运动训练或可

  来自英国的一项前瞻性研究表明,桡动脉导管术与动脉内皮剥脱相关,可减弱桡动脉的低血流介导的血管收缩(L-FMC),表明L-FMC的内皮依赖性。此外,该研究首次报道了运动训练对桡动脉血管扩张和括约肌功能的有益影响。研究于2012年9月25日在线发表于《循环﹒介入》(Circ Interventions)杂志。

  桡动脉导管术与内皮剥脱和血管舒张功能受损相关联,而导管术后的运动训练或可改善动脉功能。然而,导管术和随后的运动训练对的低血流介导的血管收缩(L-FMC)的影响尚不明确。该研究旨在评估导管术和随后发生的内皮剥脱是否能损伤桡动脉L-FMC。此外,研究还进一步评价了经桡动脉导管术后的局部手柄运动训练对桡动脉L-FMC和血流介导舒张功能(FMD)的影响。

  研究共纳入32例接受桡动脉导管术的受试者,在导管术前和术后,对受试者置管桡动脉和对侧桡动脉的L-FMC和FMD进行评估。此外,另招募18例患者随机分配到6个星期的手柄运动训练计划(N = 9)或无运动的对照周期(N = 9)。

  结果表明,置管臂术后1天的L-FMC减弱(-2.07±0.84至0.35±0.83),而非置管臂的L-FMC无变化(-0.93±0.86至-0.90±0.92,P <0.05)。在运动训练测试中,运动训练组置管臂术后7周的FMD和L-FMC均保持原有水平(FMD-术前,6.84±0.79,FMD-术后,6.85±1.16;L-FMC-术前,-2.14±1.42,L-FMC-术后,-3.58±1.04%),但对照组置管臂的L-FMC显著降低(FMD-术前,8.27±1.52;FMD-术后,4.66±0.70,P = 0.06;L-FMC-术前,- 3.26±1.19,L-FMC-术后,-1.34±1.27%,P <0.05)。

  链接:

Dawson EA, Alkarmi A, Thijssen DH, Rathore S, Marsman DE, Cable NT, Wright DJ, Green DJ.Low-Flow Mediated Constriction is Endothelium-Dependent Effects of Exercise Training After Radial Artery Catheterization.Circ Cardiovasc Interv. 2012 Sep 25

  



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