Nature & Science：科学家为克隆胚胎干细胞“突破”辩解

2013-05-28 Nature & Science 生物360

随着科学界对胚胎干细胞“突破性成果”的质疑，继在接受英国《自然》杂志采访后，论文作者又通过另一著名学术期刊《科学》杂志辩解：论文确实有错，但对研究结果无影响，论文快速发表或是因为《细胞》杂志担心论文消息泄漏。一周前，美国俄勒冈州健康和科学大学国家灵长类研究中心舒赫拉特·米塔利波夫等人在《细胞》杂志网络版上发表论文称，通过向剔除细胞核物质的卵细胞内植入皮肤细胞，成功培育出了人类胚胎干细胞。但后来

随着科学界对胚胎干细胞“突破性成果”的质疑，继在接受英国《自然》杂志采访后，论文作者又通过另一著名学术期刊《科学》杂志辩解：论文确实有错，但对研究结果无影响，论文快速发表或是因为《细胞》杂志担心论文消息泄漏。

一周前，美国俄勒冈州健康和科学大学国家灵长类研究中心舒赫拉特·米塔利波夫等人在《细胞》杂志网络版上发表论文称，通过向剔除细胞核物质的卵细胞内植入皮肤细胞，成功培育出了人类胚胎干细胞。但后来有匿名读者指出论文存在“图片重复使用”等问题，更让科学界震惊的是，论文提交仅4天就被接受。这一成果陷入质疑之中。

米塔利波夫和《细胞》杂志23日均表示，论文只有“一些小的错误”，相信不影响研究结果。但对《细胞》为什么快速发表论文，他们的解释并不让人信服。米塔利波夫对《自然》杂志称，是希望能在今年6月的一个干细胞研究国际会议上提交这一成果，而《细胞》的理由则包括论文重要和审稿人权威，等等。

对此，米塔利波夫对《科学》杂志作了进一步解释。他说，尽管他对《自然》杂志提到了6月的国际会议，但这不是快速发表的理由，也不是因为其他研究小组的竞争。论文提交日期显示为4月30日，但他在此5、6天前就提交给了《细胞》。编辑们表示感兴趣后，他才于4月30日正式提交。

米塔利波夫称，《细胞》杂志要求审稿人快速审稿，“所以他们一天之内就审完了”，只提出一些小的修改意见，因此很快改完。“《细胞》杂志可能担心论文消息泄漏，所以接受之后很快在线发表了”。

值得关注的是，米塔利波夫似乎对质疑“图片重复使用”的读者颇有微词。他说，“肉眼很难看出它们是同一张图片或不同的图片”，因此他感到好奇的是，提出问题的读者是否使用了图像检查软件，“我多希望曾用这种软件检查一下我们的论文”。

两个因素使米塔利波夫的成果引人注目：首先这是第一次采用克隆技术制造人类胚胎干细胞，可能引发“克隆人”隐忧;其次他们的成果与8年前韩国黄禹锡造假事件很相似。米塔利波夫接受《自然》、《科学》两份影响最大的综合性学术期刊采访，看来是希望至少在业内尽快平息风波。

原文检索：

ScienceInsider: Mislabeled Images Bedevil Landmark Cloning Paper

NatureNews: Stem-cell cloner acknowledges errors in groundbreaking paper

Cell: Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer.

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2014-04-02 aids221

#克隆#

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2013-06-07 liye789132251

#Nat#

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2013-05-30 ailian1202

#胚胎#

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2013-05-30 zhaojie88

#胚胎干细胞#

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2013-05-30 jichang

#SCIE#

39 0

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