EuroPrevent:头发白了,还与心脏病风险增高有关?

2017-04-11 佚名 中国生物技术网

在2017年的EuroPrevent会议上发表的一项研究表明,男性白发与心脏病风险增高有关。



在2017年的EuroPrevent会议上发表的一项研究表明,男性白发与心脏病风险增高有关。

埃及开罗大学的心脏病学家Irini Samuel博士说:“衰老是不可避免的冠心病危险因素,与衰老相关的皮肤病学症状能够预示风险增加。需要更多的研究关注与疾病风险相关的皮肤症状,从而使我们能够更早地干预血管疾病的进程。”

动脉粥样硬化与头发变白拥有类似的机制,比如DNA修复受损、氧化压力、炎症、激素变化以及功能细胞衰老等。该研究评估了冠状动脉疾病患者中的白发程度,并以此判断白发是否能够成为这种疾病的独立风险标记。

这是一项前瞻性观测研究,有545名成年男性参与,他们接受了多层螺旋CT扫描冠状动脉造影术检查,根据是否患有冠状动脉疾病以及白发的程度,他们被分为若干小组。

白发程度被分为五个等级:1 = 纯黑色头发;2 = 黑色比白色多;3 = 黑白相等;4 = 白色比黑色多;5 = 纯白色头发。每位患者的白发程度由两位独立的观察者决定。

研究人员还收集了关于传统血管风险因素的数据,包括高血压糖尿病、吸烟、血脂异常、家族冠状动脉疾病史。

研究人员发现,更高的白发程度(大于等于3)与冠状动脉疾病风险增高相关,而这与实际年龄和已有的冠状动脉疾病风险因素无关。冠状动脉疾病患者在统计学意义上白发程度更高,冠状动脉钙化程度也更高。

在多变量回归分析中,年龄、白发程度、高血压和血脂异常都是动脉粥样硬化冠状动脉疾病的独立预测指标,只有年龄是白发程度的独立预测指标。

Samuel博士说:“动脉粥样硬化和白发发生的生物通路类似,而它们都会随着年龄增长而概率增加。我们的发现表明,不论实际年龄如何,白发能够预示生物年龄,也能够作为心血管疾病风险的警示。高冠状动脉疾病风险的无症状患者应该进行定期检查,通过进行预防治疗的方式避免早期的心脏问题。”

她补充说:“我们需要与皮肤科医生合作做进一步的研究,以更加了解导致头发变白的致病基因和潜在环境因素。还需要有更大规模的男女都参加的研究,在不考虑其他已知心血管疾病风险因素的情况下确定白发与心血管疾病之间的关系。”

她总结说:“如果我们的发现被证实,那么对白发程度评价进行标准化,就可以用来预测冠状动脉疾病。”

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    2018-01-01 lhlxtx
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    2017-04-13 qindq
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    2017-04-13 liuxiaona
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    2017-04-13 liuxiaona

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