Heart:直立性低血压与全因死亡风险显著升高相关

2013-07-29 高晓方 译 cmt

  中国首都医科大学附属北京安贞医院和贵阳医学院附属医院的学者进行的一项荟萃分析表明,直立性低血压与全因死亡风险显著升高具有相关性,并且此效应部分由经典危险因素所介导。论文于7月22日在线发表于《心脏》(Heart)。 直立性低血压与死亡风险升高可能相关,但既往队列研究结果并不一致。研究者对Medline、Embase数据库和相关文献进行了检索,并纳入了评估直立性低血压与死亡风险相关

直立性低血压
 

中国首都医科大学附属北京安贞医院和贵阳医学院附属医院的学者进行的一项荟萃分析表明,直立性低血压与全因死亡风险显著升高具有相关性,并且此效应部分由经典危险因素所介导。论文于7月22日在线发表于《心脏》(Heart)。

直立性低血压与死亡风险升高可能相关,但既往队列研究结果并不一致。研究者对Medline、Embase数据库和相关文献进行了检索,并纳入了评估直立性低血压与死亡风险相关性的队列研究。

结果显示,共有9项队列研究符合纳入标准,其中包括56125例受试者和11580例死亡。汇总结果提示,基线时存在直立性低血压与全因死亡风险升高显著相关(校正危险比[RR] 1.40;P<0.001)。亚组分析提示,与经典危险因素未充分校正的研究相比,充分校正研究中直立性低血压与全因死亡的相关性较弱。尽管直立性低血压与心血管死亡无显著相关性(RR 1.20;P=0.47),但伴直立性低血压者的非心血管死亡风险显著升高(RR 1.18;P=0.05)。

Xin W, Lin Z, Mi S.Orthostatic hypotension and mortality risk: a meta-analysis of cohort studies.Heart. 2013 Jul 22. [Epub ahead of print]PMID:23878177

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    2013-07-31 仁者大医
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    2013-07-31 slcumt