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Science：哺乳动物环状RNA基因座的缺失导致miRNA失调并影响脑功能

2017-08-23 MedSci MedSci原创

环状RNA脑功能
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通常在哺乳动物脑中有数百个环状RNA（circRNA）保守表达且高丰富。在本项研究中，研究人员发现在人和小鼠脑中，环状RNA Cdr1as被miR-7和miR-671大量结合。

近日，国际杂志《Science》在线发表了一篇关于环状RNA体内功能的研究，并发现哺乳动物环状RNA基因座的缺失导致miRNA失调并影响脑功能。

通常在哺乳动物脑中有数百个环状RNA（circRNA）保守表达且高丰富。在本项研究中，研究人员发现在人和小鼠脑中，环状RNA Cdr1as被miR-7和miR-671大量结合。当从小鼠基因组中去除Cdr1as基因座时，敲除动物表现出受损的感觉运动门控，能够滤除与神经精神障碍相关的不必要信息的能力不足。电生理记录显示功能障碍性突触传播。在所分析的所有脑区域中，microRNAs miR-7和miR-671的表达特异性地转录后失调。即刻早期基因的表达，如miR-7靶基因Fos，在Cdr1as缺陷性大脑中高表达，这为行为表型提供可能的分子基础。

研究数据表明了体内的功能缺失的circRNA表型，并显示circRNA和miRNA之间的相互作用对于正常脑功能是重要的。

原始出处：

Monika Piwecka. et.al. Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.

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    2017-10-27 smallant2002

    #miR#

    0

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    2017-08-25 Homburg

    #miRNA#

    0

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    2017-08-25 jichang

    #SCIE#

    0

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    2017-08-25 ms1467340776200723

    #脑功能#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1930504, encodeId=59571930504f2, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Oct 27 01:42:00 CST 2017, time=2017-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312311, encodeId=364e131231156, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375667, encodeId=1f5813e566787, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442424, encodeId=c0c214424247f, content=<a href='/topic/show?id=dfae84e3003' target=_blank style='color:#2F92EE;'>#脑功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84730, encryptionId=dfae84e3003, topicName=脑功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00224929300, createdName=ms1467340776200723, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513998, encodeId=a2a6151399826, content=<a href='/topic/show?id=845339961b7' target=_blank style='color:#2F92EE;'>#哺乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39961, encryptionId=845339961b7, topicName=哺乳)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8fd10610597, createdName=ms1065684921169360, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516749, encodeId=f5cd1516e4946, content=<a href='/topic/show?id=2ef539962d7' target=_blank style='color:#2F92EE;'>#哺乳动物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39962, encryptionId=2ef539962d7, topicName=哺乳动物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=762011007983, createdName=ms6279672939590805, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599451, encodeId=4edd15994519e, content=<a href='/topic/show?id=b70f41e41b1' target=_blank style='color:#2F92EE;'>#基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41741, encryptionId=b70f41e41b1, topicName=基因座)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236548, encodeId=9dfe236548f7, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Thu Aug 24 07:34:22 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236341, encodeId=daf423634198, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Wed Aug 23 10:32:51 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-25 ms1065684921169360

    #哺乳#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1930504, encodeId=59571930504f2, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Oct 27 01:42:00 CST 2017, time=2017-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312311, encodeId=364e131231156, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375667, encodeId=1f5813e566787, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442424, encodeId=c0c214424247f, content=<a href='/topic/show?id=dfae84e3003' target=_blank style='color:#2F92EE;'>#脑功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84730, encryptionId=dfae84e3003, topicName=脑功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00224929300, createdName=ms1467340776200723, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513998, encodeId=a2a6151399826, content=<a href='/topic/show?id=845339961b7' target=_blank style='color:#2F92EE;'>#哺乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39961, encryptionId=845339961b7, topicName=哺乳)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8fd10610597, createdName=ms1065684921169360, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516749, encodeId=f5cd1516e4946, content=<a href='/topic/show?id=2ef539962d7' target=_blank style='color:#2F92EE;'>#哺乳动物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39962, encryptionId=2ef539962d7, topicName=哺乳动物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=762011007983, createdName=ms6279672939590805, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599451, encodeId=4edd15994519e, content=<a href='/topic/show?id=b70f41e41b1' target=_blank style='color:#2F92EE;'>#基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41741, encryptionId=b70f41e41b1, topicName=基因座)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236548, encodeId=9dfe236548f7, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Thu Aug 24 07:34:22 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236341, encodeId=daf423634198, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Wed Aug 23 10:32:51 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-25 ms6279672939590805

    #哺乳动物#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1930504, encodeId=59571930504f2, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Oct 27 01:42:00 CST 2017, time=2017-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312311, encodeId=364e131231156, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375667, encodeId=1f5813e566787, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442424, encodeId=c0c214424247f, content=<a href='/topic/show?id=dfae84e3003' target=_blank style='color:#2F92EE;'>#脑功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84730, encryptionId=dfae84e3003, topicName=脑功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00224929300, createdName=ms1467340776200723, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513998, encodeId=a2a6151399826, content=<a href='/topic/show?id=845339961b7' target=_blank style='color:#2F92EE;'>#哺乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39961, encryptionId=845339961b7, topicName=哺乳)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8fd10610597, createdName=ms1065684921169360, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516749, encodeId=f5cd1516e4946, content=<a href='/topic/show?id=2ef539962d7' target=_blank style='color:#2F92EE;'>#哺乳动物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39962, encryptionId=2ef539962d7, topicName=哺乳动物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=762011007983, createdName=ms6279672939590805, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599451, encodeId=4edd15994519e, content=<a href='/topic/show?id=b70f41e41b1' target=_blank style='color:#2F92EE;'>#基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41741, encryptionId=b70f41e41b1, topicName=基因座)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236548, encodeId=9dfe236548f7, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Thu Aug 24 07:34:22 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236341, encodeId=daf423634198, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Wed Aug 23 10:32:51 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-25 医者仁心

    #基因座#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1930504, encodeId=59571930504f2, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Oct 27 01:42:00 CST 2017, time=2017-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312311, encodeId=364e131231156, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375667, encodeId=1f5813e566787, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442424, encodeId=c0c214424247f, content=<a href='/topic/show?id=dfae84e3003' target=_blank style='color:#2F92EE;'>#脑功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84730, encryptionId=dfae84e3003, topicName=脑功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00224929300, createdName=ms1467340776200723, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513998, encodeId=a2a6151399826, content=<a href='/topic/show?id=845339961b7' target=_blank style='color:#2F92EE;'>#哺乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39961, encryptionId=845339961b7, topicName=哺乳)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8fd10610597, createdName=ms1065684921169360, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516749, encodeId=f5cd1516e4946, content=<a href='/topic/show?id=2ef539962d7' target=_blank style='color:#2F92EE;'>#哺乳动物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39962, encryptionId=2ef539962d7, topicName=哺乳动物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=762011007983, createdName=ms6279672939590805, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599451, encodeId=4edd15994519e, content=<a href='/topic/show?id=b70f41e41b1' target=_blank style='color:#2F92EE;'>#基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41741, encryptionId=b70f41e41b1, topicName=基因座)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Fri Aug 25 00:42:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236548, encodeId=9dfe236548f7, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Thu Aug 24 07:34:22 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236341, encodeId=daf423634198, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Wed Aug 23 10:32:51 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-24 meiliwuxian

    学习一下

    0

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    2017-08-23 1771ae4158m

    学习一下很不错

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