IGLH:CD81和CD58在儿童B淋巴细胞白血病检测中的作用?

2018-05-30 MedSci MedSci原创

在B淋巴细胞白血病中,已被证明微小残留病灶(MRD)是许多研究儿童和成人的临床结果的有力预测因子。在本研究中,我们对86例被诊断的患儿进行了评估,并比较了CD81、CD58、CD19、CD34、CD20和CD38在MRD检测中的表达。 我们对86例B淋巴细胞白血病患者进行了评估,对MRD使用多色流式细胞术进行了诊断研究和缓解研究。我们用连续稀释法确定了异常淋巴母细胞的检测限度。我们也在一个亚

在B淋巴细胞白血病中,已被证明微小残留病灶(MRD)是许多研究儿童和成人的临床结果的有力预测因子。在本研究中,我们对86例被诊断的患儿进行了评估,并比较了CD81、CD58、CD19、CD34、CD20和CD38在MRD检测中的表达。 我们对86例B淋巴细胞白血病患者进行了评估,对MRD使用多色流式细胞术进行了诊断研究和缓解研究。我们用连续稀释法确定了异常淋巴母细胞的检测限度。我们也在一个亚组比较了流式细胞术的发现与分子MRD检测。 我们发现,可以通过CD45、CD19、CD34、CD10、CD20、CD38、CD58和CD81的组合,来解决86个病例中85例的血液病和淋巴细胞之间的差异。我们使用流式细胞仪检测到异常B淋巴细胞的数量为0.002%。通过分子方法与MRD的比较,发现了流式细胞术的高一致性。 我们的研究强调了在B淋巴细胞白血病中使用多种标志物来检测MRD的重要性。我们的研究结果表明,除了CD19、CD34、CD20、CD38和CD10之外,CD58和CD81都对MRD检测有帮助。 原始出处: E. Tsitsikov , et. al.Role of CD81 and CD

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    2023-05-25 haha1919 来自广西

    非常好,获益良多

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=2138986, encodeId=4ec02138986e1, content=非常好,获益良多, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/z4Inou22Tqh793Pj9r6iap5jxYUGHcP9cddQdjq71nz5heYeNFhya65doXhyxV4y0gC1XDRgQp2xO6H3XCGA7Jw/132, createdBy=a5192347075, createdName=haha1919, createdTime=Thu May 25 14:11:50 CST 2023, time=2023-05-25, status=1, ipAttribution=广西), GetPortalCommentsPageByObjectIdResponse(id=2020130, encodeId=b34f202013046, content=<a href='/topic/show?id=c1ef38337f' target=_blank style='color:#2F92EE;'>#B淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3833, encryptionId=c1ef38337f, topicName=B淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Sat Apr 27 23:28:00 CST 2019, time=2019-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997899, encodeId=1faa199e89962, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Wed Aug 01 19:28:00 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755574, encodeId=76411e5557455, content=<a href='/topic/show?id=26a938319c' target=_blank style='color:#2F92EE;'>#B淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3831, encryptionId=26a938319c, topicName=B淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a9736969025, createdName=fengting15, createdTime=Wed Aug 15 06:28:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302168, encodeId=8cc41302168c8, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Fri Jun 01 11:28:00 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605382, encodeId=ca26160538282, content=<a href='/topic/show?id=94c9436340' target=_blank style='color:#2F92EE;'>#CD8#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4363, encryptionId=94c9436340, topicName=CD8)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4bac19388006, createdName=ms691033630344116, createdTime=Fri Jun 01 11:28:00 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320438, encodeId=9cd032043882, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Jun 01 06:39:03 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320112, encodeId=0ecc320112c1, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Thu May 31 02:20:23 CST 2018, time=2018-05-31, status=1, ipAttribution=)]
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    2018-06-01 三生有幸9135

    学习一下谢谢分享

    0

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    学习了.谢谢分享

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