IGEM公司获得750000英镑资助,研发针对HER2的抗癌IgE单抗

2019-04-02 不详 MedSci原创

IGEM Therapeutics已获得Innovate UK Biomedical Catalyst Primer Award的750000英镑资助,用于开发针对HER2的新型IgE抗体。

IGEM Therapeutics已获得Innovate UK Biomedical Catalyst Primer Award的750000英镑资助,用于开发针对HER2的新型IgE抗体。

HER2是在临床验证过的癌症抗原,可在多种肿瘤类型上表达,包括乳腺癌卵巢癌癌。

由于目前市售的抗HER2 IgG单抗仅能够治疗表达高水平HER2抗原的癌症患者,而大多数表达中度或低水平HER2的癌症患者不能用抗HER2 IgG单抗治疗。因此,IGEM正在开发与HER2结合的新型人IgE抗体。

IGEM创始人Sophia Karagiannis博士在伦敦国王学院的实验室进行的临床前研究已经证明,与IgG相比,许多IgE抗体具有更高的疗效。该公司还在开发针对叶酸受体α和CSPG-4的抗癌IgE抗体。

IGEM首席执行官Tim Wilson博士评论说:"IGEM是使用IgE抗体治疗癌症的先驱。我们很高兴获得Innovate UK的第二笔资助。我们的目标是利用IgE介导的免疫反应,为严重疾病患者提供新的、安全有效的治疗药物。"

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    2019-04-04 lqvr
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    2019-04-04 zhenjiu124