Stroke:高血压患者的颈动脉内膜中层厚度与首发卒中风险

2020-01-18 xing.T MedSci原创

由此可见,高血压患者基线cIMT与首发卒中风险之间存在显著的正相关。在那些具有较高平均动脉压或舒张压水平的患者中,这种关联甚至更强。

近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,这项研究旨在调查平均颈动脉内膜中层厚度(cIMT)与首发卒中风险之间的关系,并评估高血压患者的任何可能的效应调节因素。

这项分析共纳入了11547名中国卒中一级预防试验(CSPPT)中无卒中史的高血压参与者。主要结局为卒中。

在4.4年的中位随访中,共确定了726例卒中患者,其中631例为缺血性患者,90例为出血性患者。平均cIMT每增加一个SD与首次卒中(风险比[HR]为1.11 [95%CI为1.03-1.20])和首次缺血性卒中(HR为1.10 [95%CI为1.01–1.20])的风险之间呈正相关。此外,当将cIMT分类为四分位数时,相比于第1个四分位数(<0.66 mm)的参与者,第2到第4四分位数(≥0.66 mm)的参与者首次卒中(HR为1.31 [95%CI为1.06-1.61])和首次出血性卒中(HR为2.25 [95%CI为1.11-4.58])的风险较高。更重要的是,在平均动脉压([五分位数5]≥109.3与<109.3 mmHg,P相互作用=0.024)或舒张压([五分位数5]≥90.7与<90.7 mm Hg,P相互作用= 0.009))较高的受试者中,cIMT与首次卒中之间的关联更强。

由此可见,高血压患者基线cIMT与首发卒中风险之间存在显著的正相关。在那些具有较高平均动脉压或舒张压水平的患者中,这种关联甚至更强。

原始出处:

Pengfei Sun.et al.Carotid Intima-Media Thickness and the Risk of First Stroke in Patients With Hypertension.stroke.2020.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.026587

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encodeId=6eb91045929e6, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Sat Jan 18 16:56:00 CST 2020, time=2020-01-18, status=1, ipAttribution=)]
    2020-01-20 njwbhuang

    感谢分享!

    0

  5. 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encodeId=6eb91045929e6, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Sat Jan 18 16:56:00 CST 2020, time=2020-01-18, status=1, ipAttribution=)]
  8. 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encodeId=f5533e829186, content=学习了,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Sat Jan 18 20:07:55 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026542, encodeId=bfd11026542ce, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Jan 18 16:56:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045929, encodeId=6eb91045929e6, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Sat Jan 18 16:56:00 CST 2020, time=2020-01-18, status=1, ipAttribution=)]
    2020-01-18 qingfengqishi5

    学习了,学习了

    0

  9. 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encodeId=f5533e829186, content=学习了,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Sat Jan 18 20:07:55 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026542, encodeId=bfd11026542ce, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Jan 18 16:56:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045929, encodeId=6eb91045929e6, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Sat Jan 18 16:56:00 CST 2020, time=2020-01-18, status=1, ipAttribution=)]
    2020-01-18 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  10. 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encodeId=f5533e829186, content=学习了,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Sat Jan 18 20:07:55 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026542, encodeId=bfd11026542ce, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Jan 18 16:56:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045929, encodeId=6eb91045929e6, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Sat Jan 18 16:56:00 CST 2020, time=2020-01-18, status=1, ipAttribution=)]
    2020-01-18 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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