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樊嘉：一组MicroRNA可以作为肝癌早期标志物（附MedSci点评）

2011-11-30 MedSci原创 MedSci原创

樊嘉肝癌早期标志物
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 MedSci评论：     虽然，说这个成果两年内可应用于临床，为时过早了，但是确实给大家的临床和科研工作带来全新的思路！以往我们一直希望发现一个单一的“biomarker”，实际上相当困难！象肿瘤领域，至今为止真正的经典肿瘤标志物还是50年前发现的那些，如CEA，AFP等，新型标志物发现相当困难。最近几年，流行通过蛋白质组学方法发现b

 MedSci评论：     虽然，说这个成果两年内可应用于临床，为时过早了，但是确实给大家的临床和科研工作带来全新的思路！以往我们一直希望发现一个单一的“biomarker”，实际上相当困难！象肿瘤领域，至今为止真正的经典肿瘤标志物还是50年前发现的那些，如CEA，AFP等，新型标志物发现相当困难。最近几年，流行通过蛋白质组学方法发现biomarker，虽然科研成果很多，但是能应用于临床的少之又少！包括前两年的重大发现，GP73（高尔基蛋白73）可能会作为肝癌的特异性标志物（目前已获临床应用），这是较少成功应用于临床的标志物。     不过，樊嘉教授采用一组标志物进行诊断，这是重要的创新之一。当然，这也给未来临床应用带来巨大挑战。但这不失为临床科研的重要思路方法！     但是这篇文章的研究就没有缺陷了吗？虽然发表在国际一流杂志上，但仍然不完美，与临床应用还有相当的距离。如果要证明它们是“biomarker”的话，其一要有特异性，其二是敏感性。细读樊嘉教授的文章，选择了健康人

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  1. [GetPortalCommentsPageByObjectIdResponse(id=13068, encodeId=41cb1306855, content=肝癌是我国高发人群，microRNA在肝癌中研究过程很有价值，但作为早期筛查成本太高，难以普及, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Sat Dec 13 14:44:00 CST 2014, time=2014-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857275, encodeId=bc02185e2754a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Thu Nov 08 12:39:00 CST 2012, time=2012-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084062, encodeId=ad18208406240, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Sep 05 03:39:00 CST 2012, time=2012-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840716, encodeId=2c8a1840e168c, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Wed Nov 14 09:39:00 CST 2012, time=2012-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435641, encodeId=4183143564103, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Dec 02 00:39:00 CST 2011, time=2011-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605628, encodeId=0261160562838, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Dec 02 00:39:00 CST 2011, time=2011-12-02, status=1, ipAttribution=)]
    2014-12-13 cbp

    肝癌是我国高发人群，microRNA在肝癌中研究过程很有价值，但作为早期筛查成本太高，难以普及

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=13068, encodeId=41cb1306855, content=肝癌是我国高发人群，microRNA在肝癌中研究过程很有价值，但作为早期筛查成本太高，难以普及, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Sat Dec 13 14:44:00 CST 2014, time=2014-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857275, encodeId=bc02185e2754a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Thu Nov 08 12:39:00 CST 2012, time=2012-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084062, encodeId=ad18208406240, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Sep 05 03:39:00 CST 2012, time=2012-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840716, encodeId=2c8a1840e168c, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Wed Nov 14 09:39:00 CST 2012, time=2012-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435641, encodeId=4183143564103, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Dec 02 00:39:00 CST 2011, time=2011-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605628, encodeId=0261160562838, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Dec 02 00:39:00 CST 2011, time=2011-12-02, status=1, ipAttribution=)]
    2012-11-08 jiafufeng@yaho

    #CRO#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=13068, encodeId=41cb1306855, content=肝癌是我国高发人群，microRNA在肝癌中研究过程很有价值，但作为早期筛查成本太高，难以普及, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Sat Dec 13 14:44:00 CST 2014, time=2014-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857275, encodeId=bc02185e2754a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Thu Nov 08 12:39:00 CST 2012, time=2012-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084062, encodeId=ad18208406240, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Sep 05 03:39:00 CST 2012, time=2012-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840716, encodeId=2c8a1840e168c, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Wed Nov 14 09:39:00 CST 2012, time=2012-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435641, encodeId=4183143564103, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Dec 02 00:39:00 CST 2011, time=2011-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605628, encodeId=0261160562838, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Dec 02 00:39:00 CST 2011, time=2011-12-02, status=1, ipAttribution=)]
    2012-09-05 xjy02

    #Micro#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=13068, encodeId=41cb1306855, content=肝癌是我国高发人群，microRNA在肝癌中研究过程很有价值，但作为早期筛查成本太高，难以普及, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Sat Dec 13 14:44:00 CST 2014, time=2014-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857275, encodeId=bc02185e2754a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Thu Nov 08 12:39:00 CST 2012, time=2012-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084062, encodeId=ad18208406240, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Sep 05 03:39:00 CST 2012, time=2012-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840716, encodeId=2c8a1840e168c, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Wed Nov 14 09:39:00 CST 2012, time=2012-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435641, encodeId=4183143564103, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Dec 02 00:39:00 CST 2011, time=2011-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605628, encodeId=0261160562838, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Dec 02 00:39:00 CST 2011, time=2011-12-02, status=1, ipAttribution=)]
    2012-11-14 hukaixun

    #标志物#

    0

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    2011-12-02 zhouqu_8

    #microRNA#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=13068, encodeId=41cb1306855, content=肝癌是我国高发人群，microRNA在肝癌中研究过程很有价值，但作为早期筛查成本太高，难以普及, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Sat Dec 13 14:44:00 CST 2014, time=2014-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857275, encodeId=bc02185e2754a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Thu Nov 08 12:39:00 CST 2012, time=2012-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084062, encodeId=ad18208406240, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Sep 05 03:39:00 CST 2012, time=2012-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840716, encodeId=2c8a1840e168c, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Wed Nov 14 09:39:00 CST 2012, time=2012-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435641, encodeId=4183143564103, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Dec 02 00:39:00 CST 2011, time=2011-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605628, encodeId=0261160562838, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Dec 02 00:39:00 CST 2011, time=2011-12-02, status=1, ipAttribution=)]
    2011-12-02 ms3994565386320060

    #Med#

    0