CGH:影响胃腺癌患者生存时间的因素有哪些?

2014-01-17 佚名 不详

2013年12月刊发在Clin Gastroenterol Hepatol杂志上的一项回顾性队列研究的结果显示,在胃腺癌患者中,男性以及贲门腺癌的患者的预期寿命更短,胃腺癌早期发现可增加患者的预期寿命。 胃腺癌是常见死因之一,尤其是在亚洲国家。但关于胃癌生存时间影响因素的研究却并不多。为此,来自台湾国立成功大学的研究人员进行了一项回顾性队列研究。 研究人员收集了

2013年12月刊发在Clin Gastroenterol Hepatol杂志上的一项回顾性队列研究的结果显示,在胃腺癌患者中,男性以及贲门腺癌的患者的预期寿命更短,胃腺癌早期发现可增加患者的预期寿命。

胃腺癌是常见死因之一,尤其是在亚洲国家。但关于胃癌生存时间影响因素的研究却并不多。为此,来自台湾国立成功大学的研究人员进行了一项回顾性队列研究。

研究人员收集了台湾全民癌症与死亡率注册研究中1998年至2007年确诊的35,576名(男性23,173人,女性12,403人)胃癌患者的相关数据。根据2010年的生存曲线制作了回归曲线并评估受试者的生存时间。基于性别、肿瘤类型和部位比较了预期寿命(LE)和潜在寿命损失年(EYLL)。

结果显示,男性患者胃癌的累积发病率高于女性。所有胃癌患者中88.6%为腺癌。贲门部肿瘤对LE减少和EYLL增加的影响较其他部位肿瘤更为显著。女性患者如能早期确诊胃癌,其在LE和EYLL方面的获益显著优于男性患者。据研究人员估算,如果90%的胃腺癌能够在发病初期得到及时诊治,那么女性和男性患者的LE将分别增加2.62年和1.97年。

研究者总结该项研究的不足之处包括:未纳入对照组,通过数据库相关资料建立的统计学模型对生存时间进行评估,结论可能存在地域上的局限性,早期确诊者生存时间的评估是建立在90%早期胃癌能够被治愈的前提之下,可能有点不太现实。

原文出处:

David J. Bjorkman“What Factors Influence Survival in Gastric Adenocarcinoma?” jwatch January 9, 2014.

Wei–Ying Chen, Hsiu–Chi Cheng, Jung–Der Wang, Bor–Shyang Sheue.Factors that affect life expectancy of patients with gastric adenocarcinoma.Clin Gastroenterol Hepatol. 2013 Dec;11(12):1595-600. doi: 10.1016/j.cgh.2013.05.036. Epub 2013 Jun 28.

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    2014-07-04 chendoc242
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