Ann Intern Med:中年时预防糖尿病和控制血糖有助于减轻20年后认知减退

2014-12-12 高晓方翻译 中国医学论坛报

美国一项研究表明,中年时糖尿病预防和血糖控制有可能减轻老年时认知减退。论文12月2日发表于《内科学年鉴》[Ann Intern Med2014,161(11):785]。 研究共纳入13351例基线年龄为48~67岁的受试者,通过糖化血红蛋白(HbA1c)临床分类确定未诊断糖尿病、糖尿病前期及糖尿病患者血糖控制情况。利用延迟词语回忆、数字符号替换和言语流畅测试评估认知性能。 结果为

美国一项研究表明,中年时糖尿病预防和血糖控制有可能减轻老年时认知减退。论文12月2日发表于《内科学年鉴》[Ann Intern Med2014,161(11):785]。

研究共纳入13351例基线年龄为48~67岁的受试者,通过糖化血红蛋白(HbA1c)临床分类确定未诊断糖尿病糖尿病前期及糖尿病患者血糖控制情况。利用延迟词语回忆、数字符号替换和言语流畅测试评估认知性能。

结果为,与无糖尿病者相比,中年时患糖尿病与20年后认知减退加重19%具相关性。糖尿病前期患者的认知减退程度显著高于HbA1c<5.7%者,糖尿病控制不佳者认知减退程度亦高于糖尿病控制良好者(P=0.071)。糖尿病持续时间较长者后期认知减退更重(趋势P<0.001)。不同种族间认知减退率无显著差异。

原始出处:

Rawlings AM, Sharrett AR, Schneider AL, Coresh J, Albert M, Couper D, Griswold M, Gottesman RF, Wagenknecht LE, Windham BG, Selvin E.Diabetes in midlife and cognitive change over 20 years: a cohort study.Ann Intern Med. 2014 Dec 2;161(11):785-93. doi: 10.7326/M14-0737.

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    2015-06-08 ljjj1053

    好好学习学习

    0

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    2015-04-11 x35042875

    他们的研究数据表明增加肠道中肠促胰素分泌细胞的数目,有可能成为改善血糖代谢的新型治疗方案。

    0

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