Diabetes Care:糖尿病患者骨折风险高再获证实

2014-05-16 CMT心血管 中国医学论坛报手机报

来自中国台湾的一项研究显示,糖尿病与骨折相关,糖尿病患者骨折后不良事件和死亡增加。论文5月7日在线发表于《糖尿病护理》(Diabetes Care)杂志。 研究纳入32471例新诊断糖尿病成年患者和64942名非糖尿病成人的数据,随访652530人-年。结果为,糖尿病患者和非糖尿病者的骨折发生率分别为24.2例/1000人-年和17.1例/1000人-年(P<0.0001)。与非糖尿病者相

来自中国台湾的一项研究显示,糖尿病与骨折相关,糖尿病患者骨折后不良事件和死亡增加。论文5月7日在线发表于《糖尿病护理》(Diabetes Care)杂志。

Ta-Liang Chen教授等采用台湾国家健康保险研究数据库,鉴定了32471名在2000-2003年新诊断为糖尿病的患者。从该数据库中随机选择年龄和性别匹配的64942名成人作为对照。从医疗索赔记录中确定2000至2008年期间受试者的骨折事件,计算糖尿病患者发生骨折的校正风险比和95%可信区间。Ta-Liang Chen教授等于2004至2010年期间进行一项的巢式病例对照研究,受试者为17002例骨折后接受修复手术治疗的患者,计算糖尿病和非糖尿病患者骨折后不良事件的校正比值比和95%可信区间。

结果显示,在652530人年次随访期内,有12772例新诊断的骨折病例。糖尿病和非糖尿病人群骨折发生率分别为24.2/1000人年和17.1/1000人年。与非糖尿病患者比较,糖尿病患者经校正的骨折HR值为1.66。糖尿病相关的骨折后深部创口感染、败血症和死亡ORs值分别为1.34、1.42和1.27。

研究表明,糖尿病与骨折相关。糖尿病患者骨折后不良事件发生率增多、后续死亡率升高。Ta-Liang Chen教授建议这个易感人群需要进行骨折和骨折后不良事件预防。

原始出处:


Liao CC1, Lin CS, Shih CC, Yeh CC, Chang YC, Lee YW, Chen TL.Increased Risk of Fracture and Postfracture Adverse Events in Patients With Diabetes: Two Nationwide Population-Based Retrospective Cohort Studies.Diabetes Care. 2014 May 7. [Epub ahead of print]

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    2015-04-11 x35042875

    国真实妊娠糖尿病患病率应该在这两种方案得到的患病率之间

    0

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    2015-04-13 智智灵药
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