J Periodontol:拔牙后再生过程中早期愈合牙龈组织灌注和生物标志物

2017-11-11 MedSci MedSci原创

尽管有再生手术,拔牙后牙槽骨吸收,且主要影响颊侧。为了更好地了解可能的决定因素,这个前瞻性病例系列评估拔牙后牙龈血液灌注和组织分子反应。

尽管有再生手术,拔牙后牙槽骨吸收,且主要影响颊侧。为了更好地了解可能的决定因素,这个前瞻性病例系列评估拔牙后牙龈血液灌注和组织分子反应。

方法:招募成人在上颌非磨牙区单颗牙拔除部位接受植骨。临床指标包括:1)探诊深度(PD); 2)角化组织宽度(KT); 3)组织生物型(TB);和4)菌斑水平。临床评估伤口闭合。采用激光多普勒血流仪(LDF)测量龈沟液血流灌注。对伤口液(WF)和牙龈活检分别分析相关分子标记的蛋白质水平和基因表达。通过放射学评价(锥形束计算机断层扫描)骨的愈合。经过4个月的愈合。

结果分析了15名患者的数据。术后未观察到PD,KT或TB的并发症和改变。 LDF显示灌注减少,继而持续1个月的充血(P≤0.05)。血管生成素-2,白细胞介素-8(IL-8),肿瘤坏死因子-α(TNF-α)和血管内皮生长因子的WF水平在第6天达到峰值(P≤0.05),此后降低。只有IL-8和TNF-α表现出基因表达增加。线性骨变化可以忽略不计。骨体积改变最小但有统计学意义,当使用膜时骨吸收更多(P = 0.05)。

结论:拔牙后骨再生时,牙龈血液灌注遵循缺血再灌注模型。血管生成因子水平的短暂增加和持续的充血表征软组织反应。这些软组织反应不能确定放射学的骨改变。

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    2017-11-25 feather89
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    2017-11-15 半夏微凉

    学习了谢谢分享

    0

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    2017-11-13 xre2013
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    2017-11-12 飛歌

    学习的还是不错

    0

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