Nat Commun:复旦大学研究者发现对抗寨卡病毒的潜在治疗方案

2017-07-26 佚名 Nature自然科研

本周发表在《自然-通讯》的一篇论文A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses公布了一种寨卡病毒抑制剂,它成功降低了怀孕小鼠和胚胎中的病毒水平。实验证明抑制剂不会对怀孕小鼠造成伤害。这些发现表明这种药物有望进入临床前开发阶段。

本周发表在《自然-通讯》的一篇论文A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses公布了一种寨卡病毒抑制剂,它成功降低了怀孕小鼠和胚胎中的病毒水平。实验证明抑制剂不会对怀孕小鼠造成伤害。这些发现表明这种药物有望进入临床前开发阶段。

感染寨卡病毒的孕妇能在怀孕期间将病毒传播到体内的胚胎中,可能造成胎儿的先天缺陷。目前,没有哪种用于治疗寨卡病毒感染的疫苗或药物被批准使用。复旦大学的姜世勃及同事发现一种使寨卡病毒颗粒丧失活性并阻止病毒进入细胞的潜在药物。他们证明这种药物能减少寨卡病毒在怀孕小鼠体内向胚胎的传播。在接受药物治疗期间,药物分子并没有对怀孕小鼠或胚胎产生任何副作用。

Z2抑制剂穿透怀孕小鼠胎盘屏障的能力。


Yu et al.

虽然还需要更进一步的研究来测试这种抑制剂对人类的安全性和有效性,但是使病毒粒子失去活性的治疗方式能够被用于研发针对高危人群(尤其是孕妇)中寨卡病毒感染的新治疗方案。

原始出处:Yufeng Yu, Yong-Qiang Deng, Peng Zou, et al. A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses. Nature Communications(2017) 8

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    2017-09-08 liuli5079
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    2017-09-05 liye789132251
  4. 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target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Fri Jul 28 08:19:00 CST 2017, time=2017-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226609, encodeId=ad5d226609cc, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jul 26 18:07:03 CST 2017, time=2017-07-26, status=1, ipAttribution=), 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    2018-06-20 stfoxst
  5. 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    2017-08-02 虈亣靌

    谢谢分享,很不错。

    0

  6. 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target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Fri Jul 28 08:19:00 CST 2017, time=2017-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226609, encodeId=ad5d226609cc, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jul 26 18:07:03 CST 2017, time=2017-07-26, status=1, ipAttribution=), 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  7. 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target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Fri Jul 28 08:19:00 CST 2017, time=2017-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226609, encodeId=ad5d226609cc, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jul 26 18:07:03 CST 2017, time=2017-07-26, status=1, ipAttribution=), 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  8. 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target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Fri Jul 28 08:19:00 CST 2017, time=2017-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226609, encodeId=ad5d226609cc, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jul 26 18:07:03 CST 2017, time=2017-07-26, status=1, ipAttribution=), 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    2017-07-28 saikp
  9. 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target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Fri Jul 28 08:19:00 CST 2017, time=2017-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226609, encodeId=ad5d226609cc, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jul 26 18:07:03 CST 2017, time=2017-07-26, status=1, ipAttribution=), 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    2017-07-26 明月清辉

    谢谢分享,学习了

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=226599, encodeId=dfa9226599bd, content=本周发表在《自然-通讯》的一篇论文A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses公布了一种寨卡病毒抑制剂,它成功降低了怀孕小鼠和胚胎中的病毒水平。实验证明抑制剂不会对怀孕小鼠造成伤害。这些发现表明这种药物有望进入临床前开发阶段。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Wed Jul 26 17:31:45 CST 2017, time=2017-07-26, status=1, ipAttribution=)]
    2017-07-26 Julie W

    本周发表在《自然-通讯》的一篇论文A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses公布了一种寨卡病毒抑制剂,它成功降低了怀孕小鼠和胚胎中的病毒水平。实验证明抑制剂不会对怀孕小鼠造成伤害。这些发现表明这种药物有望进入临床前开发阶段。

    0

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