JACC:左心室辅助装置可作为进行性心衰患者康复的桥梁

2017-04-17 xiangting MedSci原创

相当数量的患者外植LVAD后可以达到与正常人相当的心功能和运动能力。

左心室辅助装置(LVADs)已被用作进行性心衰患者的有效治疗方案,作为移植的桥梁、主要治疗手段,对某些患者可作为康复的桥梁。近日心血管领域权威杂志Journal of the American College of Cardiology发表了一篇文章,旨在评估LVAD作为康复方案的患者是否可以获得与正常人相当的心功能和运动能力。

共入组58例男性患者,其中18例植入连续性血流LVAD,16例外植LVAD,24例准备接受心脏移植(HTx)和97例正常对照进行最大限度心肺运动试验,试验中连续测量呼吸气体交换和非侵入性血液动力学数据。心功能由峰值心脏功率输出(平均动脉压×心输出量)表示,运动能力由峰值O2消耗表示。

所有患者均运动到力竭,平均峰值气体交换比> 1.10。正常对照组和外植LVAD患者的峰值心脏功率输出明显高于其他患者(正常组5.35±0.95W;外植组3.45±0.72W;LVAD植入2.37±0.68W;HTx 1.31±0.31W;P<0.05) 。峰值氧消耗也是如此(正常组36.4±10.3 ml/kg/min;外植组29.8±5.9 ml/kg/min;LVAD植入20.5±4.3 ml/kg/min; HTx 12.0±2.2 ml/kg/min,P<0.05)。在LVAD外植组中,38%的患者达到了峰值心脏功率输出,69%的峰值氧耗量在正常范围。

由此可见,相当数量的患者外植LVAD后可以达到与正常人相当的心功能和运动能力。

原始出处:

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    2017-05-31 hbwxf

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