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ILC 2016：熊去氧胆酸不能降低原发性胆汁性肝硬化死亡率

2016-04-14 Mechront 译 MedSci原创

原发性胆汁性肝硬化熊去氧胆酸死亡
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2016年国际肝病会议称，系统性回顾表明，熊去氧胆酸（UDCA）不能降低原发性硬化性胆管炎或原发性胆汁性肝硬化(PBC)的死亡率。塞尔维亚临床中心临床胃肠病学和肝脏病学的Jelena Nincevic博士和同事对UDCA治疗PBC的研究进行了系统回顾，评估UDCA对全因死亡率、肝移植等的影响。最终纳入了16篇临床研究，涉及1,476名患者，其中14篇研究比较了UDCA和安慰剂(n = 1,198)

2016年国际肝病会议称，系统性回顾表明，熊去氧胆酸（UDCA）不能降低原发性硬化性胆管炎或原发性胆汁性肝硬化(PBC)的死亡率。

塞尔维亚临床中心临床胃肠病学和肝脏病学的Jelena Nincevic博士和同事对UDCA治疗PBC的研究进行了系统回顾，评估UDCA对全因死亡率、肝移植等的影响。

最终纳入了16篇临床研究，涉及1,476名患者，其中14篇研究比较了UDCA和安慰剂(n = 1,198)，还有2篇研究比较了UDCA和无干预(n = 278)。系统回顾纳入了12篇临床研究，包括偏倚高风险的研究。

荟萃分析和亚组分析数据显示，UDCA治疗组与对照组相比，全因死亡率或肝移植风险RR=0.96 (95% CI, 0.74-1.25)。两组严重不良事件发生率无差异。

瘙痒发生率的荟萃分析显示，UDCA治疗组和对照组分别为321和309名患者伴瘙痒，RR=0.96 (95% CI, 0.84-1.09)，所以UDCA也不能改善PBC患者的瘙痒发生率。

不过UDCA也并不是一无是处，研究者发现，该药物可轻度改善患者的胆红素和血浆碱性磷酸酶。

原始出处：

Nincevic J. Joint Workshop: EASL-CHBG. Presented at: International Liver Congress; April 13-17, 2016; Barcelona.

UDCA fails to improve mortality in primary biliary cirrhosis.Healio.April 13, 2016


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    2016-10-16 jiyangfei

    #原发性#

    0

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    2017-02-17 hb2008ye

    #胆汁性#

    0

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Thu Apr 14 22:04:00 CST 2016, time=2016-04-14, status=1, ipAttribution=)]
    2016-09-28 yahu

    #肝硬化死亡率#

    0

  4. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Thu Apr 14 22:04:00 CST 2016, time=2016-04-14, status=1, ipAttribution=)]
    2016-04-27 zyszy1111

    看看

    0

  5. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Thu Apr 14 22:04:00 CST 2016, time=2016-04-14, status=1, ipAttribution=)]
    2016-04-16 zhanfl

    #熊去氧胆酸#

    0

  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Thu Apr 14 22:04:00 CST 2016, time=2016-04-14, status=1, ipAttribution=)]
    2016-04-16 108807375_62823132

    #胆汁#

    0

  7. 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authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160227/IMG56D1078DD4F344111.jpg, createdBy=80b71692457, createdName=壹生, createdTime=Fri Apr 15 07:53:00 CST 2016, time=2016-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78427, encodeId=ae09e8427c6, content=很不错的知识，该药常用, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAF6ogXiceRzVH2drFiaow6ibIukSoyFPpHDd9xdGSOj8hcZ/0, createdBy=41f01710035, createdName=醉清风, createdTime=Fri Apr 15 02:39:00 CST 2016, time=2016-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78393, encodeId=3baee839307, content=学习了长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Thu Apr 14 22:04:00 CST 2016, time=2016-04-14, status=1, ipAttribution=)]
    2016-04-15 1de3b290m83(暂无匿称)

    降胆汁

    0

  8. 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authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160227/IMG56D1078DD4F344111.jpg, createdBy=80b71692457, createdName=壹生, createdTime=Fri Apr 15 07:53:00 CST 2016, time=2016-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78427, encodeId=ae09e8427c6, content=很不错的知识，该药常用, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAF6ogXiceRzVH2drFiaow6ibIukSoyFPpHDd9xdGSOj8hcZ/0, createdBy=41f01710035, createdName=醉清风, createdTime=Fri Apr 15 02:39:00 CST 2016, time=2016-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78393, encodeId=3baee839307, content=学习了长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Thu Apr 14 22:04:00 CST 2016, time=2016-04-14, status=1, ipAttribution=)]
    2016-04-15 壹生

    不过我们观察lx不过我观察疗效可以

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1846489, encodeId=54d418464896a, content=<a href='/topic/show?id=d3a33e0306d' target=_blank style='color:#2F92EE;'>#原发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37030, encryptionId=d3a33e0306d, topicName=原发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Sun Oct 16 13:30:00 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809363, encodeId=23fd1809363c1, content=<a href='/topic/show?id=5eba834e876' target=_blank style='color:#2F92EE;'>#胆汁性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83478, encryptionId=5eba834e876, topicName=胆汁性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, 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authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160227/IMG56D1078DD4F344111.jpg, createdBy=80b71692457, createdName=壹生, createdTime=Fri Apr 15 07:53:00 CST 2016, time=2016-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78427, encodeId=ae09e8427c6, content=很不错的知识，该药常用, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAF6ogXiceRzVH2drFiaow6ibIukSoyFPpHDd9xdGSOj8hcZ/0, createdBy=41f01710035, createdName=醉清风, createdTime=Fri Apr 15 02:39:00 CST 2016, time=2016-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78393, encodeId=3baee839307, content=学习了长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Thu Apr 14 22:04:00 CST 2016, time=2016-04-14, status=1, ipAttribution=)]
    2016-04-15 醉清风

    很不错的知识，该药常用

    0

  10. 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authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160227/IMG56D1078DD4F344111.jpg, createdBy=80b71692457, createdName=壹生, createdTime=Fri Apr 15 07:53:00 CST 2016, time=2016-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78427, encodeId=ae09e8427c6, content=很不错的知识，该药常用, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAF6ogXiceRzVH2drFiaow6ibIukSoyFPpHDd9xdGSOj8hcZ/0, createdBy=41f01710035, createdName=醉清风, createdTime=Fri Apr 15 02:39:00 CST 2016, time=2016-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78393, encodeId=3baee839307, content=学习了长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Thu Apr 14 22:04:00 CST 2016, time=2016-04-14, status=1, ipAttribution=)]
    2016-04-14 hekzn

    学习了长知识了

    0

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