J Clin Periodontol:同种异体犬牙周膜来源细胞在牙周再生中的应用

2018-03-28 MedSci MedSci原创

这种体内实验研究的目的是在类似的实验模型中评估将同种异体牙周膜源性细胞结合到异种骨替代物中的细胞疗法的再生潜能。

这种体内实验研究的目的是在类似的实验模型中评估将同种异体牙周膜源性细胞结合到异种骨替代物中的细胞疗法的再生潜能。

在9只比格犬中,PIII和PIV周围形成临界尺寸6毫米的前牙槽牙周缺损。将所得前牙槽骨缺损随机用接种在10%胶原的去蛋白牛骨矿物质(DBBM-C)(试验组)或无细胞DBBM-C(对照组)的1.4×106同种异体犬牙周膜来源细胞治疗。在3个月时取标本,并研究组织学结果。

结果:组织学分析表明,两组均完全分歧闭合的很少,即牙周再生的范围位于缺损的顶端三分之一。在试验组和对照组中,分歧区的牙周再生量分别为1.93±1.14mm(17%)和2.35±1.74mm(22%)(p = 0.37)。新牙骨质形成量分别为4.49±1.56mm(41%)和4.97±1.05mm(47%)(p = 0.45),无显着差异。

结论:该实验研究无法证实同种异体细胞疗法在冠方牙周再生中的附加价值。

原始出处:

Javier Nunez, et al. Cell therapy with allogenic canine periodontal ligament‐derived cells in periodontal regeneration of critical size defects. Journal of Clinical Periodontology. 2018 April. doi:10.1111/jcpe.12863

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    2018-07-31 feather89
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    2018-07-09 xqptu
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objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Wed Mar 28 06:58:31 CST 2018, time=2018-03-28, status=1, ipAttribution=)]
    2018-03-29 半夏微凉

    学习了谢谢分享

    0

  7. 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content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Mar 28 08:22:45 CST 2018, time=2018-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300447, encodeId=70d230044e89, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Mar 28 07:36:14 CST 2018, time=2018-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300412, encodeId=160c3004124d, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Wed Mar 28 06:58:31 CST 2018, time=2018-03-28, status=1, ipAttribution=)]
    2018-03-28 wzb521zf

    一起学习学习

    0

  8. 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content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Mar 28 08:22:45 CST 2018, time=2018-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300447, encodeId=70d230044e89, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Mar 28 07:36:14 CST 2018, time=2018-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300412, encodeId=160c3004124d, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Wed Mar 28 06:58:31 CST 2018, time=2018-03-28, status=1, ipAttribution=)]
    2018-03-28 龙胆草

    学习谢谢分享

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Wed Mar 28 06:58:31 CST 2018, time=2018-03-28, status=1, ipAttribution=)]
    2018-03-28 1dd8c52fm63(暂无匿称)

    了解了解.学习学习

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Wed Mar 28 06:58:31 CST 2018, time=2018-03-28, status=1, ipAttribution=)]
    2018-03-28 chunjianf

    学习了.谢谢分享

    0

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J Periodontal Res:在小鼠和人的牙周膜中,Ⅰ型胶原具有独特的翻译后特征

调节牙周韧带(PDL)中胶原蛋白交联的生物化学途径的具体细节尚未完全确定。需要更好地了解胶原蛋白翻译后修饰,使PDL具有不同的组织特性,以了解牙周病中PDL破坏的致病机制。使用质谱法进行了检测人类和小鼠PDL I型胶原的翻译后表型。

J Periodontol:富含生长因子的血浆结合引导组织再生术治疗慢性牙周炎患者骨缺损的叠加效应

牙周再生可以定义为完全恢复失去的牙周组织到其原有的结构和功能。已经提出了各种治疗方式来实现。富含生长因子的血浆(PRGF)是促进牙周损伤恢复的生长因子的浓缩悬浮液。本研究的目的是评估PRGF结合引导性组织再生(GTR)相对于单纯GTR对于治疗慢性牙周炎(CP)患者的骨内缺损(IBD)的影响。

J Periodontal Res:可生物降解的明胶/β-磷酸三钙海绵结合重组人成纤维细胞生长因子-2治疗衰退型缺损:犬类半口对照研究

通过使用人重组(rh)生长因子技术的组织工程有望提供一种治疗牙龈退缩的方法。成纤维细胞生长因子-2(FGF-2)可能有促进牙周再生的能力。已经开发出明胶/β-三磷酸钙(明胶/β-TCP)海绵用来控制生长因子的释放。本研究通过比较rhFGF-2结合的明胶/β-TCP海绵与单独的支架,以评价在人工建模的狗衰退型缺损中rhFGF-2的牙周再生功效。