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Neurology：早期亨廷顿病进展评估方法研究

2017-11-25 zhangfan MedSci原创

亨廷顿病纹状体脑萎缩临床进展
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研究认为，通过运动、认知和全脑功能的综合评估可以充分评估早期亨廷顿病患者临床特征，采取对症治疗缓解病情进展

近日研究人员利用前瞻性观察性队列研究和安慰剂组随机双盲临床试验的数据确定早期亨廷顿病（HD）临床进展评估的改进措施。

研究考察了1668名早期HD患者资料，患者临床随访30-36个月，通过亨廷顿病统一评定量表(UHDRS)、非UHDRS临床评价以及进行性脑萎缩评估考察患者病情进展。

研究发现对运动、认知和全脑功能衰退的综合评价是最有效的临床进展特征评估方法。这种方法可以最有效的体现渐进纹状体脑萎缩情况。

研究认为，通过运动、认知和全脑功能的综合评估可以充分评估早期亨廷顿病患者临床特征，采取对症治疗缓解病情进展。

原始出处：


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    2018-10-08 kksonne

    #评估方法#

    0

  2. 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    2018-05-14 yinhl1978

    #Neurol#

    0

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    2017-11-28 tanxingdoctor

    学习啦!谢谢分享!

    0

  4. 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encryptionId=c83a2455270, topicName=亨廷顿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sun Nov 26 23:08:00 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622753, encodeId=50091622e5380, content=<a href='/topic/show?id=4a6e2454879' target=_blank style='color:#2F92EE;'>#亨廷顿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24548, encryptionId=4a6e2454879, topicName=亨廷顿)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sun Nov 26 23:08:00 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264491, encodeId=9f2f26449130, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, 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level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sun Nov 26 07:42:59 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264197, encodeId=f8cf26419e05, content=近日研究人员利用前瞻性观察性队列研究和安慰剂组随机双盲临床试验的数据确定早期亨廷顿病(HD)临床进展评估的改进措施., beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Nov 25 12:54:51 CST 2017, time=2017-11-25, status=1, ipAttribution=), 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    2017-11-26 hongbochen

    #亨廷顿病#

    0

  5. 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level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sun Nov 26 07:42:59 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264197, encodeId=f8cf26419e05, content=近日研究人员利用前瞻性观察性队列研究和安慰剂组随机双盲临床试验的数据确定早期亨廷顿病(HD)临床进展评估的改进措施., beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Nov 25 12:54:51 CST 2017, time=2017-11-25, status=1, ipAttribution=), 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    2017-11-26 爆笑小医

    #亨廷顿#

    0

  6. 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level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sun Nov 26 07:42:59 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264197, encodeId=f8cf26419e05, content=近日研究人员利用前瞻性观察性队列研究和安慰剂组随机双盲临床试验的数据确定早期亨廷顿病(HD)临床进展评估的改进措施., beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Nov 25 12:54:51 CST 2017, time=2017-11-25, status=1, ipAttribution=), 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    2017-11-26 戒馋，懒，贪

    谢谢分享学习了

    0

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sun Nov 26 11:09:42 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264404, encodeId=979826440490, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sun Nov 26 07:43:02 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264403, encodeId=f7ff264403ec, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sun Nov 26 07:42:59 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264197, encodeId=f8cf26419e05, content=近日研究人员利用前瞻性观察性队列研究和安慰剂组随机双盲临床试验的数据确定早期亨廷顿病(HD)临床进展评估的改进措施., beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Nov 25 12:54:51 CST 2017, time=2017-11-25, status=1, ipAttribution=), 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    2017-11-26 榄枷檬

    谢谢分享

    0

  8. 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    2017-11-26 榄枷檬

    学习学习

    0

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    2017-11-25 有备才能无患

    近日研究人员利用前瞻性观察性队列研究和安慰剂组随机双盲临床试验的数据确定早期亨廷顿病(HD)临床进展评估的改进措施.

    0

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