British J Cancer:大肚子的人更容易得癌症?

2017-05-25 生物谷 生物谷

根据最近发表在《British Journal of Cancer》杂志上的一篇文章,科学家们发现了身体中部囤积的脂肪可以用于预测癌症发生的风险。结果显示,腰围每增加11厘米,患肥胖症相关癌症的风险将提高13%。对于肠癌来说,腰围每增加8厘米即伴随着患癌风险15%的提升。 身体乘载过多的脂肪会改变性激素的分泌水平,例如雌二醇以及睾酮等,进而引

根据最近发表在《British Journal of Cancer》杂志上的一篇文章,科学家们发现了身体中部囤积的脂肪可以用于预测癌症发生的风险。结果显示,腰围每增加11厘米,患肥胖症相关癌症的风险将提高13%。对于肠癌来说,腰围每增加8厘米即伴随着患癌风险15%的提升。

身体乘载过多的脂肪会改变性激素的分泌水平,例如雌二醇以及睾酮等,进而引发胰岛素水平的生高以及炎症反应的发生。这些症状都会提高癌症的发生风险。


(图片摘自www.pixabay.com)

事实上,这是第一次对肥胖相关癌症进行标准化的研究。通过利用创新性的手段,来自IARC-WHO的研究者们提供了三种指征肥胖的指标,包括BMI,腰围以及腰臀比。在老年人群体中,这三种指标在预测肥胖相关癌症发生风险上具有相同的效果。该研究囊括了43000名参与者,进行了长达12年的研究。其中有超过1600名人被诊断患有肥胖相关的癌症。

该文章的第一作者,Heinz Freisling 博士称:“我们的发现表明BMI与脂肪的囤积部位都是很好的预测肥胖相关癌症发生风险的指标。特别地,药物囤积的脂肪对于特定类型的癌症的预测效果很好,但需要进一步的研究验证”。“为了更好地反映其中的生物学机制,我们需要进行深入的探究。但不管如何,我们的研究提供了额外的证据表明体型是会影响特定癌症的发生风险的”。

超重或肥胖引发的癌症是仅次于抽烟的第二大癌症诱因,涉及的癌症类型包括肠胃癌乳腺癌以及胰腺癌等等13种。Julie Sharp博士称:“这一发现为大众提供了新的预防癌症发生的线索。虽然体重与癌症的发生之间没有确定的因果关系,但保持健康的体重能够带来很多益处。只要在饮食以及运动上做微小的改变就能够达到长期的身体健康的目的,又何乐而不为呢?”


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    2017-06-15 laoli

    学习了,谢谢分享!

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    2017-05-28 ylzr123

    认真学习,不断进步,把经验分享给同好。点赞了!

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    2017-05-27 184****9840

    减肥减肥减肥,重要事情说三遍!

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    2017-05-26 luominglian113

    学习了,谢谢分享

    0

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    2017-05-26 changjiu

    腹部脂肪是健康杀手

    0

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FASEB J:控制“好”“坏”脂肪形成——糖尿病治疗新法门

近日,一批来自瑞士苏黎世应用科技大学细胞生物学和组织工程中心的研究人员表示,他们发现棕色脂肪组织细胞表面存在的两种受体可以作为潜在的治疗靶点,对于这些细胞表面受体的靶向作用可以促进棕色脂肪组织(BAT)(“良好”脂肪)的代谢与转化。这两种称为TRPM8和TRPP3的细胞表面受体都与人类机体中棕色脂肪组织的产生密切相关。同时,这类细胞表面受体也可能被某些食物中的天然分子或者人工分子化合物药物所激活,

Oncotarget: 脂肪代谢抑制可以使前列腺癌细胞对抗雄激素阻断敏感

前列腺癌(PCa)是西方男性最常见的恶性疾病并且是癌症相关死亡的第二主要原因。对于那些患有转移性激素抵抗性PCa(mCRPC)的病人,存活率是很低的,这也使得对mCRPC新的治疗方法的鉴定变得非常重要。最近,有研究人员发现,通过肉毒碱棕榈酰转移酶诱导的脂肪氧化(CPT1)缺陷可以引起生长和侵入性减弱,强化了脂肪氧化在PCa生长燃料的角色。研究人员利用免疫组化技术发现,与良性组织比较,CPT1A同工

Brit J Cancer:身体哪个部位脂肪多容易诱发癌症?

科学家发现,根据英国“癌症杂志”今天发表的研究报告,腰腹部携带脂肪可能与身体质量指数(BMI)一样,都是癌症的预测指标。