J Hepatol:术前肝胆的核磁共振可对因肝细胞癌而进行肝脏移植的患者的肿瘤复发进行危险分层

2018-02-11 MedSci MedSci原创

研究结论:术前肝胆核磁共振的放射学特征可以为患者肿瘤复发的风险进行分层,无论是在米兰的标准内还是米兰标准外进行的肝移植。

肝胆核磁共振成像除了提供肿瘤大小和数目等信息外,有可能具有预后指导意义。本研究的目的是采用MRI了解移植前患者放射学特征,以讨论是否可以对因肝细胞癌(HCC)而进行肝脏移植的患者的肿瘤复发进行危险分层。

研究方法:本研究共纳入100例肝移植患者。这些患者术前做过增强MRI。回顾这些患者肿瘤的大小,数目,形态学类型(结节状,延伸的结节状,融合的多结节等),卫星结节,非光滑肿瘤的边缘,动脉期的瘤旁增强,瘤旁低信号强度,表观扩散系数等资料。主要研究终点是肿瘤再复发。

研究结果:在多变量调整模型中,卫星结节(危险比[HR], 3.07, 95%置信区间[CI], 1.14-8.24)和瘤旁低信号(HR, 4.53;95% CI, 1.52-13.4)被认为是与肿瘤复发相关的独立因素。存在任何这些放射学特征(卫星结节或瘤旁低信号)与较高的肿瘤复发率相关(72.5%Vs15.4%在第3年,P < 0.001)。根据米兰标准将患者进行分层,高危放射学特征的出现与患者较高的肿瘤再复发率相关,无论是根据米兰标准进行肝移植的患者(66.7% vs. 11.6% 在第3年, P < 0.001, n = 68),还是未按米兰标准进行肝移植的患者(75.5% vs. 28.6%在第3年, P < 0.001, n = 32)。

研究结论:术前肝胆核磁共振的放射学特征可以为患者肿瘤复发的风险进行分层,无论是在米兰的标准内还是米兰标准外进行的肝移植。

原始出处

Kim AY, Sinn DH, Jeong WK, et al. Hepatobiliary MRI as novel selection criteria in liver transplantation for hepatocellular carcinoma. J Hepatol, 2018, Feb 2. doi: 10.1016/j.jhep.2018.01.024.

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    2018-07-26 xjy02
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    2018-02-13 gwc384