Eur Heart J:预测缺血性卒中发生的风险:ATRIA评分优于CHADS2和CHA2DS2-VASc

2016-05-31 phylis 译 MedSci原创

目的:心房颤动(AF)患者中,对是否应用抗凝药物治疗进行优化,以更好地进行脑卒中风险预测。两大加利福尼亚社区AF队列开发并验证了ATRIA卒中风险评分(ATRIA)的开发和验证。研究者应用比较瑞典国家AF(SAF)队列比较ATRIA, CHADS2和CHA2DS2-VASc评分。方法:研究者检查了所有瑞典住院治疗或医院门诊的患者,这些患者在2005年7月到2010年12月诊断为AF。从综合的国家数

目的:在房颤(AF)患者中,对是否应用抗凝药物治疗进行优化,以更好地进行脑卒中风险预测。两个加利福尼亚社区AF队列中的ATRIA卒中风险评分(ATRIA)的开发和验证。研究者把它与瑞典国家AF(SAF)队列比较ATRIA、CHADS2和CHA2DS2-VASc评分。

方法:研究者检查了所有瑞典住院治疗或医院门诊的患者,这些患者在2005年7月到2010年12月诊断为AF。从综合的国家数据库中确定变量。应用C-指数和净重新分类改善(NRI)评估危险分数。

结果:该队列包括152153名未接受华法林治疗的房颤患者。总体而言,11053例发生急性缺血性中风,平均速度为3.2% /年,高于加利福尼亚队列的2% /年。使用整个分数,ATRIA的C指数较好 0.708(0.704-0.713),明显优于CHADS2 0.690(0.685-0.695)或CHA2DS2-VASc 0.694(0.690-0.700)。使用低/中/高风险的界值点,ATRIA的C指数虽有所降低但仍优于其他分数。与CHADS2相比,净重新分类改善为ATRIA 0.16(0.14-0.17),与CHA2DS2-VASc相比,净重新分类改善为0.21(0.20-0.23)。当设置界值点以更好地适应人群的卒中发生率时,净重新分类改善降低。

结论:在这个SAF队列中,ATRIA分数预测缺血性卒中风险优于CHADS2和CHA2DS2-VASc。然而,人群卒中率不同,评分的相对性能的也不同。可能需要优化设置的界值点分数,以更好地适应当地人口的卒中率。

原始出处:

Aspberg S, Chang Y, et al. Comparison of the ATRIA, CHADS2, and CHA2DS2-VASc stroke risk scores in predicting ischaemic stroke in a large Swedish cohort of patients with atrial fibrillation. Eur Heart J. 2016 Mar 3.


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    2017-07-05 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

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beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Tue Aug 09 20:52:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892757, encodeId=fd8d1892e5717, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sat Jun 25 10:52:00 CST 2016, time=2016-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1782910, encodeId=032b1e82910b4, content=<a href='/topic/show?id=c1fa456550' target=_blank style='color:#2F92EE;'>#CHA2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4565, encryptionId=c1fa456550, topicName=CHA2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Mon Apr 24 08:52:00 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356075, encodeId=afc313560e5bc, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jun 02 07:52:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562367, encodeId=15d4156236e72, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Jun 02 07:52:00 CST 2016, time=2016-06-02, status=1, ipAttribution=)]
    2016-10-13 ylzr123

    拜读了,受益匪浅,点个赞!

    0

  5. 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  6. 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encodeId=032b1e82910b4, content=<a href='/topic/show?id=c1fa456550' target=_blank style='color:#2F92EE;'>#CHA2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4565, encryptionId=c1fa456550, topicName=CHA2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Mon Apr 24 08:52:00 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356075, encodeId=afc313560e5bc, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jun 02 07:52:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562367, encodeId=15d4156236e72, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Jun 02 07:52:00 CST 2016, time=2016-06-02, status=1, ipAttribution=)]
    2016-08-09 quxin068
  7. 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time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562367, encodeId=15d4156236e72, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Jun 02 07:52:00 CST 2016, time=2016-06-02, status=1, ipAttribution=)]
  8. 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encodeId=032b1e82910b4, content=<a href='/topic/show?id=c1fa456550' target=_blank style='color:#2F92EE;'>#CHA2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4565, encryptionId=c1fa456550, topicName=CHA2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Mon Apr 24 08:52:00 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356075, encodeId=afc313560e5bc, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jun 02 07:52:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562367, encodeId=15d4156236e72, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Jun 02 07:52:00 CST 2016, time=2016-06-02, status=1, ipAttribution=)]
    2017-04-24 huperzia
  9. 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encodeId=032b1e82910b4, content=<a href='/topic/show?id=c1fa456550' target=_blank style='color:#2F92EE;'>#CHA2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4565, encryptionId=c1fa456550, topicName=CHA2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Mon Apr 24 08:52:00 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356075, encodeId=afc313560e5bc, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jun 02 07:52:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562367, encodeId=15d4156236e72, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Jun 02 07:52:00 CST 2016, time=2016-06-02, status=1, ipAttribution=)]
    2016-06-02 zhaojie88
  10. 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time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562367, encodeId=15d4156236e72, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Jun 02 07:52:00 CST 2016, time=2016-06-02, status=1, ipAttribution=)]
    2016-06-02 slcumt

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感染是导致急性缺血性卒中死亡的主要原因,但目前还不清楚是否预防性应用抗生素治疗可以改善预后。研究者旨在评估预防性抗生素治疗对感染的发生率和短期死亡率的影响。这是对18岁以上急性缺血性脑卒中患者进行的前瞻性多中心现实世界的分析,这些患者入院时美国国立卫生院卒中量表(NIHSS)> 11分。排除入院时或者入院前一个月有感染,入院时腋温超过37°C,有慢性炎症性疾病或应用糖皮质激素治疗的患者。11

Stroke:CHA2DS2-VASc评分为1的患者,或可应用新型口服抗凝药

背景:CHA2DS2-VASc评分的目的是改善房颤患者的缺血性卒中风险分层,识别那些可以安全地放弃口服抗凝药的患者。口服抗凝治疗指南对CHA2DS2-VASC分值为1的治疗仍不确定。研究者进行了一项系统回顾和荟萃分析房颤患者,CHA2DS2-VASc评分为0,1或2分,未进行口服抗凝治疗,患者缺血性卒中风险。方法:研究者检索了从数据库开始日期到2015年4月15日,MEDLINE、EMBASE、P

PLoS One: SAMe-TT2R2评分预测中国房颤患者华法林治疗的控制情况

背景:华法林用于房颤患者(AF)卒中预防的安全性和有效性取决于治疗范围的时间(TTR)。研究者旨在评估SAMe-TT2R2分数对中国应用华法林的房颤患者的预测能力,其TTR是众所周知的差。方法:这是一个单中心回顾性研究。1997到2011间诊断为非瓣膜性房颤患者,根据SAMe-TT2R2分数将其进行分层,采用Rosendaal方法计算TTR。TTR> 70% ,SAMe-TT2R2分数的预测

Stroke:血管紧张素受体阻断剂和β-阻断剂与老年人卒中发生相关

背景:研究旨在确定65岁老年人,不同抗高血压药物及长期血压变异率(BPV)与卒中事件发生的相关性。在老年人≥65年。方法:样本包括5951名受试者(平均年龄74岁,60%名女性),受试者至少服用1种药物治疗高血压(3727/5951)或收缩压>140毫米汞柱或舒张压>90毫米汞柱。在随访的12年中,评估受试者致命性和非致命性卒中事件的发生。对9种类别的降压药,采用变异系数和回归计算BPV(BPVr

PLoS One:臭氧浓度升高与卒中发生增加相关

背景:日益升高的臭氧浓度已破坏人类健康和生态系统。尽管臭氧呈现昼夜变异,多数研究报告当天或后一天缺血性脑卒中的发生,仅白天臭氧浓度相关。研究者调查了臭氧的昼夜变化对缺血性卒中发生的影响。方法:研究者在韩国汉城的一家三级医院,招募2008年1月1日到2014年12月31日的1734例患者。研究者评估每个时间段和平均参数(7年的研究中获得),卒中发生时温度和污染物的差异。结果:相比于其他时间段,13:

Ann Neurol:阿尔茨海默症和小血管缺血性卒中存在共同的遗传易感性

目的:越来越多的证据表明,阿尔茨海默氏症(AD)和缺血性卒中(IS)之间的流行病学和病理学相关。研究者调查的证据表明,这两种疾病存在共同的遗传因素。方法:应用METASTROKE +((15916例IS病例和68826例对照)和IGAP(17008例AD患者和37154名对照)研究中的数据,进行全基因组关联研究(GWAS),研究者评估AD和IS的相关性。研究者可获得基因水平的数据(4610例IS患