Sci Rep:系统挖掘中草药抗癌潜力,发现300余种潜在化合物

2016-06-24 MedSci MedSci原创

中科院昆明动物所黄京飞课题组在从传统中草药中发掘抗癌植物和化合物研究中取得进展。相关成果日前在线发表于《科学报告》杂志。 我国传统中药数据库记录了2000多种药用植物。但在传统中草药中,只有小部分药用植物被充分系统地研究过。 针对这一现状,黄京飞课题组首先建立了一个抗肿瘤药物预测平台。基于该平台,他们开发了新的预测肿瘤靶标的方法,并成功预测了新的肺癌靶标。最近,科研人员又利用该平台和预

中科院昆明动物所黄京飞课题组在从传统中草药中发掘抗癌植物和化合物研究中取得进展。相关成果日前在线发表于《科学报告》杂志。

我国传统中药数据库记录了2000多种药用植物。但在传统中草药中,只有小部分药用植物被充分系统地研究过。

针对这一现状,黄京飞课题组首先建立了一个抗肿瘤药物预测平台。基于该平台,他们开发了新的预测肿瘤靶标的方法,并成功预测了新的肺癌靶标。最近,科研人员又利用该平台和预测方法,对传统中草药数据库中的所有药用植物及其化合物的抗癌潜力进行了系统评估和发掘。

科研人员从中预测出5278个抗癌化合物,其中前346个化合物在60个细胞系测试实验中表现出超强的抗癌活性。分析表明,有3952个化合物和已经上市的抗癌药物具有高度的结构相似性。同时,他们利用活性富集方法,鉴别出57种具有潜在抗癌活性的药用植物。这些植物广泛分布于植物界的28个科和46个属,从而极大地拓宽了抗癌药物的筛选范围。

黄京飞课题组还构建了抗癌植物和上市抗癌药物的连接网络。该网络凸显了这些植物对抗癌药物研发的支持作用,并提示这些植物具有不同的抗癌分子机制。


原始出处:

Shao-Xing Dai, Wen-Xing Li, Fei-Fei Han, Yi-Cheng Guo, Jun-Juan Zheng, Jia-Qian Liu, Qian Wang, Yue-Dong Gao, Gong-Hua Li & Jing-Fei Huang  .Scientific Reports 6, Article number: 25462 (2016)
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相关会议推荐
2016天然药物研讨会:http://www.bioon.com/z/2016natural-products/Index.shtml


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    2017-06-04 zll0637
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    2016-11-06 医张生

    中药???是留给全世界的瑰宝。感谢祖先。

    0

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    2016-09-04 ylzr123

    赞!好文章,拜读,值得深入学习!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1754657, encodeId=c75e1e54657d8, content=<a href='/topic/show?id=b5338e217cd' target=_blank style='color:#2F92EE;'>#草药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87217, encryptionId=b5338e217cd, topicName=草药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff5b36776883, createdName=zll0637, createdTime=Sun Jun 04 15:31:00 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153857, encodeId=9fe515385e5a, content=中药???是留给全世界的瑰宝。感谢祖先。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Sun Nov 06 20:42:49 CST 2016, time=2016-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906313, encodeId=9f55190631380, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Wed Mar 15 22:31:00 CST 2017, time=2017-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110839, encodeId=6b641108399a, content=赞!好文章,拜读,值得深入学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 04 14:44:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91326, encodeId=bdf29132628, content=好文章,值得收藏!, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jun 27 15:07:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91180, encodeId=add291180b9, content=好文章,值得收藏!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Sun Jun 26 15:03:00 CST 2016, time=2016-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91109, encodeId=4384911095b, content=中药宝库,作者采用芯片进行筛选,假阳线还是比较高的, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jun 25 13:20:00 CST 2016, time=2016-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91091, encodeId=edea9109137, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Jun 25 09:48:00 CST 2016, time=2016-06-25, status=1, ipAttribution=)]
    2016-06-27 oo902

    好文章,值得收藏!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1754657, encodeId=c75e1e54657d8, content=<a href='/topic/show?id=b5338e217cd' target=_blank style='color:#2F92EE;'>#草药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87217, encryptionId=b5338e217cd, topicName=草药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff5b36776883, createdName=zll0637, createdTime=Sun Jun 04 15:31:00 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153857, encodeId=9fe515385e5a, content=中药???是留给全世界的瑰宝。感谢祖先。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Sun Nov 06 20:42:49 CST 2016, time=2016-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906313, encodeId=9f55190631380, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Wed Mar 15 22:31:00 CST 2017, time=2017-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110839, encodeId=6b641108399a, content=赞!好文章,拜读,值得深入学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 04 14:44:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91326, encodeId=bdf29132628, content=好文章,值得收藏!, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jun 27 15:07:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91180, encodeId=add291180b9, content=好文章,值得收藏!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Sun Jun 26 15:03:00 CST 2016, time=2016-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91109, encodeId=4384911095b, content=中药宝库,作者采用芯片进行筛选,假阳线还是比较高的, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jun 25 13:20:00 CST 2016, time=2016-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91091, encodeId=edea9109137, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Jun 25 09:48:00 CST 2016, time=2016-06-25, status=1, ipAttribution=)]
    2016-06-26 jaysppr

    好文章,值得收藏!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1754657, encodeId=c75e1e54657d8, content=<a href='/topic/show?id=b5338e217cd' target=_blank style='color:#2F92EE;'>#草药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87217, encryptionId=b5338e217cd, topicName=草药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff5b36776883, createdName=zll0637, createdTime=Sun Jun 04 15:31:00 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153857, encodeId=9fe515385e5a, content=中药???是留给全世界的瑰宝。感谢祖先。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Sun Nov 06 20:42:49 CST 2016, time=2016-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906313, encodeId=9f55190631380, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Wed Mar 15 22:31:00 CST 2017, time=2017-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110839, encodeId=6b641108399a, content=赞!好文章,拜读,值得深入学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 04 14:44:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91326, encodeId=bdf29132628, content=好文章,值得收藏!, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jun 27 15:07:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91180, encodeId=add291180b9, content=好文章,值得收藏!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Sun Jun 26 15:03:00 CST 2016, time=2016-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91109, encodeId=4384911095b, content=中药宝库,作者采用芯片进行筛选,假阳线还是比较高的, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jun 25 13:20:00 CST 2016, time=2016-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91091, encodeId=edea9109137, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Jun 25 09:48:00 CST 2016, time=2016-06-25, status=1, ipAttribution=)]
    2016-06-25 lovetcm

    中药宝库,作者采用芯片进行筛选,假阳线还是比较高的

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1754657, encodeId=c75e1e54657d8, content=<a href='/topic/show?id=b5338e217cd' target=_blank style='color:#2F92EE;'>#草药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87217, encryptionId=b5338e217cd, topicName=草药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff5b36776883, createdName=zll0637, createdTime=Sun Jun 04 15:31:00 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153857, encodeId=9fe515385e5a, content=中药???是留给全世界的瑰宝。感谢祖先。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Sun Nov 06 20:42:49 CST 2016, time=2016-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906313, encodeId=9f55190631380, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Wed Mar 15 22:31:00 CST 2017, time=2017-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110839, encodeId=6b641108399a, content=赞!好文章,拜读,值得深入学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 04 14:44:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91326, encodeId=bdf29132628, content=好文章,值得收藏!, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jun 27 15:07:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91180, encodeId=add291180b9, content=好文章,值得收藏!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Sun Jun 26 15:03:00 CST 2016, time=2016-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91109, encodeId=4384911095b, content=中药宝库,作者采用芯片进行筛选,假阳线还是比较高的, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jun 25 13:20:00 CST 2016, time=2016-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91091, encodeId=edea9109137, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Jun 25 09:48:00 CST 2016, time=2016-06-25, status=1, ipAttribution=)]
    2016-06-25 忠诚向上

    好好学习

    0

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