SLEEP:睡眠障碍与 TBI 患者痴呆风险增加有关

2021-06-10 Viho MedSci原创

近日,一项发表在SLEEP上的,针对 700,000 多名脑外伤 (TBI) 患者进行的研究的初步结果表明,睡眠障碍患者患痴呆症的风险增加。

近日,一项发表在SLEEP上的,针 700,000 多名脑外伤 (TBI) 患者进行的研究的初步结果表明,睡眠障碍患者患痴呆症的风险增加。该研究将于 6 13 日在Virtual SLEEP 2021期间以口头报告形式呈现。SLEEP 是美国睡眠医学会和睡眠研究协会的合资企业——美国专业睡眠协会的年会。

该项回顾性研究的患者在 2003 5 月至 2013 4 月期间被送往急诊科或急诊医院并被诊断 TBI 时没有痴呆。总样本包括所有患有严重性。本研究共包括712,708名各种严重程度的TBI患者。中位年龄为 44 岁,59% 是男性。

 主要暴露是睡眠障碍,主要结果是痴呆症,两者都由国际疾病分类第十次修订版诊断来定义。睡眠障碍与痴呆症的关系通过多变量Cox比例危险模型进行分析。

 52个月的中位随访中(四分位数范围,19-86个月),32,834人(4.6%)患上了痴呆症。在控制了年龄、性别、收入水平、受伤严重程度和已知的合并症风险后,诊断出的睡眠障碍是发生痴呆症的一个重要预测因素:危险比(HR),1.250[95% CI1.146-1.363]。当结果按性别分层时,睡眠障碍与痴呆症的关系在男性中仍然显著:HR 1.255 [95% CI, 1.112-1.415],在女性患者中仍然显著。HR 1.234 [95% CI, 1.088-1.400]。对阿尔茨海默病病例定义的敏感性分析和使用FineGray竞争风险模型证实了睡眠障碍和痴呆症在两性中的关联。

 结果表明,在超过四年的中位随访期间,被诊断出睡眠障碍的 TBI 患者患痴呆症的可能性要高 25%按性别分层时的结果相似:患有睡眠障碍的男性 TBI 患者患痴呆症的风险增加 25.5%,女性 TBI 患者患痴呆症的风险增加 23.4%

 该研究是第一个报告睡眠障碍和其他因素分别对男性和女性 TBI 患者造成的风险的研究。

 我们的研究的新颖之处在于它证实了睡眠障碍与男性和女性患者发生痴呆症的关联,独立于其他已知的痴呆症风险,主要作者和主要研究员、风筝研究所附属科学家 Tatyana Mollayeva 博士说,同时她也指出,与两性痴呆发病率的密切联系表明,需要对 TBI 患者进行更有针对性的睡眠障碍风险意识,

原始出处:794 Contribution of sleep disorders to dementia incidence following traumatic brain injury: A decade-long retrospective cohort study. https://doi.org/10.1093/sleep/zsab072.791

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  1. 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    2022-02-03 1dea0131m20(暂无匿称)

    学习了

    0

  2. 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    2022-01-12 hxj0117
  3. 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    2021-06-11 ms5000001756152328

    很好👍

    0

  4. 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GetPortalCommentsPageByObjectIdResponse(id=1345045, encodeId=fa7a1345045c0, content=<a href='/topic/show?id=cf721640495' target=_blank style='color:#2F92EE;'>#SLE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16404, encryptionId=cf721640495, topicName=SLE)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Fri Jun 11 15:06:23 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972707, encodeId=31b39e270722, content=赚积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7975280135, createdName=1483f8cem53(暂无昵称), createdTime=Fri Jun 11 00:03:57 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972401, encodeId=a3589e240100, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210610/a3241b5f9a3a4daf8ae07d6fa03675a7/5300ece71ed8431789ade13ff3913d93.jpg, createdBy=3d6f5518160, createdName=ms4000001408306525, createdTime=Thu Jun 10 09:29:51 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972383, encodeId=35359e2383eb, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Jun 10 03:06:23 CST 2021, time=2021-06-10, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1189986, encodeId=569a11899867a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c11710318, createdName=1dea0131m20(暂无匿称), createdTime=Thu Feb 03 19:11:44 CST 2022, time=2022-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887284, encodeId=288e188e2841a, content=<a href='/topic/show?id=33971e181b8' target=_blank style='color:#2F92EE;'>#TBI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17181, encryptionId=33971e181b8, topicName=TBI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ac59108, createdName=hxj0117, createdTime=Wed Jan 12 11:06:23 CST 2022, time=2022-01-12, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=1345045, encodeId=fa7a1345045c0, content=<a href='/topic/show?id=cf721640495' target=_blank style='color:#2F92EE;'>#SLE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16404, encryptionId=cf721640495, topicName=SLE)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Fri Jun 11 15:06:23 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972707, encodeId=31b39e270722, content=赚积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7975280135, createdName=1483f8cem53(暂无昵称), createdTime=Fri Jun 11 00:03:57 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972401, encodeId=a3589e240100, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210610/a3241b5f9a3a4daf8ae07d6fa03675a7/5300ece71ed8431789ade13ff3913d93.jpg, createdBy=3d6f5518160, createdName=ms4000001408306525, createdTime=Thu Jun 10 09:29:51 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972383, encodeId=35359e2383eb, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Jun 10 03:06:23 CST 2021, time=2021-06-10, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1189986, encodeId=569a11899867a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c11710318, createdName=1dea0131m20(暂无匿称), createdTime=Thu Feb 03 19:11:44 CST 2022, time=2022-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887284, encodeId=288e188e2841a, content=<a href='/topic/show?id=33971e181b8' target=_blank style='color:#2F92EE;'>#TBI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17181, encryptionId=33971e181b8, topicName=TBI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ac59108, createdName=hxj0117, createdTime=Wed Jan 12 11:06:23 CST 2022, time=2022-01-12, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=1345045, encodeId=fa7a1345045c0, content=<a href='/topic/show?id=cf721640495' target=_blank style='color:#2F92EE;'>#SLE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16404, encryptionId=cf721640495, topicName=SLE)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Fri Jun 11 15:06:23 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972707, encodeId=31b39e270722, content=赚积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7975280135, createdName=1483f8cem53(暂无昵称), createdTime=Fri Jun 11 00:03:57 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972401, encodeId=a3589e240100, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210610/a3241b5f9a3a4daf8ae07d6fa03675a7/5300ece71ed8431789ade13ff3913d93.jpg, createdBy=3d6f5518160, createdName=ms4000001408306525, createdTime=Thu Jun 10 09:29:51 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972383, encodeId=35359e2383eb, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210610/faaf0b77499240d0ac8851c324db58c1/69e58b875d4749349a094a0254a3d8c4.jpg, createdBy=643c5445417, createdName=ms3000001619278799, createdTime=Thu Jun 10 08:42:08 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972351, encodeId=5dc59e235128, content=厉害啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210610/6fffdd349cc740d4a104c66bb4eecbbc/b96c236856c545cf9f9e1bed6e2bf9be.jpg, createdBy=c9885510159, createdName=天天夜夜, createdTime=Thu Jun 10 04:47:41 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048801, encodeId=753310488018c, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Jun 10 03:06:23 CST 2021, time=2021-06-10, status=1, ipAttribution=)]
    2021-06-11 1483f8cem53(暂无昵称)

    赚积分

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1189986, encodeId=569a11899867a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c11710318, createdName=1dea0131m20(暂无匿称), createdTime=Thu Feb 03 19:11:44 CST 2022, time=2022-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887284, encodeId=288e188e2841a, content=<a href='/topic/show?id=33971e181b8' target=_blank style='color:#2F92EE;'>#TBI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17181, encryptionId=33971e181b8, topicName=TBI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ac59108, createdName=hxj0117, createdTime=Wed Jan 12 11:06:23 CST 2022, time=2022-01-12, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=1345045, encodeId=fa7a1345045c0, content=<a href='/topic/show?id=cf721640495' target=_blank style='color:#2F92EE;'>#SLE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16404, encryptionId=cf721640495, topicName=SLE)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Fri Jun 11 15:06:23 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972707, encodeId=31b39e270722, content=赚积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7975280135, createdName=1483f8cem53(暂无昵称), createdTime=Fri Jun 11 00:03:57 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972401, encodeId=a3589e240100, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210610/a3241b5f9a3a4daf8ae07d6fa03675a7/5300ece71ed8431789ade13ff3913d93.jpg, createdBy=3d6f5518160, createdName=ms4000001408306525, createdTime=Thu Jun 10 09:29:51 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972383, encodeId=35359e2383eb, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210610/faaf0b77499240d0ac8851c324db58c1/69e58b875d4749349a094a0254a3d8c4.jpg, createdBy=643c5445417, createdName=ms3000001619278799, createdTime=Thu Jun 10 08:42:08 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972351, encodeId=5dc59e235128, content=厉害啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210610/6fffdd349cc740d4a104c66bb4eecbbc/b96c236856c545cf9f9e1bed6e2bf9be.jpg, createdBy=c9885510159, createdName=天天夜夜, createdTime=Thu Jun 10 04:47:41 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048801, encodeId=753310488018c, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Jun 10 03:06:23 CST 2021, time=2021-06-10, status=1, ipAttribution=)]
    2021-06-10 ms4000001408306525

    学习了

    0

  8. 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Jun 10 03:06:23 CST 2021, time=2021-06-10, status=1, ipAttribution=)]
    2021-06-10 ms3000001619278799

    学习了

    0

  9. 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createdName=1483f8cem53(暂无昵称), createdTime=Fri Jun 11 00:03:57 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972401, encodeId=a3589e240100, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210610/a3241b5f9a3a4daf8ae07d6fa03675a7/5300ece71ed8431789ade13ff3913d93.jpg, createdBy=3d6f5518160, createdName=ms4000001408306525, createdTime=Thu Jun 10 09:29:51 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972383, encodeId=35359e2383eb, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210610/faaf0b77499240d0ac8851c324db58c1/69e58b875d4749349a094a0254a3d8c4.jpg, createdBy=643c5445417, createdName=ms3000001619278799, createdTime=Thu Jun 10 08:42:08 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972351, encodeId=5dc59e235128, content=厉害啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210610/6fffdd349cc740d4a104c66bb4eecbbc/b96c236856c545cf9f9e1bed6e2bf9be.jpg, createdBy=c9885510159, createdName=天天夜夜, createdTime=Thu Jun 10 04:47:41 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048801, encodeId=753310488018c, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Jun 10 03:06:23 CST 2021, time=2021-06-10, status=1, ipAttribution=)]
    2021-06-10 天天夜夜

    厉害啊

    0

  10. 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Jun 10 03:06:23 CST 2021, time=2021-06-10, status=1, ipAttribution=)]
    2021-06-10 junJUN

    老年人痴呆何药可用??

    0

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