Crit Care:脓毒症患者的中心静脉压测量与结局改善相关

2020-07-19 MedSci原创 MedSci原创

CVP测量与败血症患者经风险调整后的28天死亡率降低相关,并且由血清乳酸的降低所介导。

中心静脉压(CVP)的测量可能是有用的临床工具。但是,CVP测量在预防败血病患者死亡率方面的作用尚未得到证实。

近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,研究人员检索了重症监护医学信息中心III(MIMIC-III)数据库,以确定具有和不具有CVP测量值的败血症患者。该研究的主要结局为28天死亡率。研究人员使用多元回归分析来阐明CVP测量值与28天死亡率之间的关系,并采用倾向评分匹配(PSM)和治疗权重的逆概率(IPTW)来验证该研究的发现。

该研究共纳入10275例患者,其中4516例患者(44%)在重症监护病房(ICU)入院24小时内接受了CVP测量。CVP组28天死亡的风险有所降低(OR为0.60(95%CI为0.51-0.70;p<0.001))。CVP组的患者在第1天接受了更多的液体,并且机械通气和使用升压药的时间较短,此外,血清乳酸水平的降低程度大于无CVP组。血清乳酸减少的调节作用在整个队列(平均因果调节效应(ACME)p=0.04)和CVP组的初始CVP水平低于8 mmHg的患者(对于ACME,p=0.04)中均很显著。

由此可见,CVP测量与败血症患者经风险调整后的28天死亡率降低相关,并且由血清乳酸的降低所介导。

原始出处:

Hui Chen.et al.Central venous pressure measurement is associated with improved outcomes in septic patients: an analysis of the MIMIC-III database.Critical Care.2020.https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03109-9

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    2020-11-19 898319336

    哪来那么大的样本量

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1698125, encodeId=b30f1698125c4, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Aug 19 08:29:50 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796997, encodeId=07bb1e96997d9, content=<a href='/topic/show?id=5a6e221853a' target=_blank style='color:#2F92EE;'>#中心静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22185, encryptionId=5a6e221853a, topicName=中心静脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sat Jun 05 03:29:50 CST 2021, time=2021-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900620, encodeId=094490062032, content=哪来那么大的样本量, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=464e4070825, createdName=898319336, createdTime=Thu Nov 19 21:39:32 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715615, encodeId=bbac1e156156f, content=<a href='/topic/show?id=83622218699' target=_blank style='color:#2F92EE;'>#中心静脉压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22186, encryptionId=83622218699, topicName=中心静脉压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5631964592, createdName=ms4657536712156177, createdTime=Sun Aug 09 22:29:50 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803888, encodeId=d28580388807, content=挖掘, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c605377477, createdName=ms5000001810105069, createdTime=Wed Jul 22 13:03:55 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516382, encodeId=e7bf15163820d, content=<a href='/topic/show?id=a5598519866' target=_blank style='color:#2F92EE;'>#脓毒症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85198, encryptionId=a5598519866, topicName=脓毒症患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dd7310955580, createdName=dlwang_26703130, createdTime=Tue Jul 21 07:29:50 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803342, encodeId=11fb803342cb, content=<a href='/topic/show?id=9d1523811e6' target=_blank style='color:#2F92EE;'>#乳酸#</a>对于重症至关重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23811, encryptionId=9d1523811e6, topicName=乳酸)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Jul 19 16:51:47 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803341, encodeId=739480334194, content=<a href='/topic/show?id=7a2f851921d' target=_blank style='color:#2F92EE;'>#脓毒症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85192, encryptionId=7a2f851921d, topicName=脓毒症)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Jul 19 16:51:07 CST 2020, time=2020-07-19, status=1, ipAttribution=)]
    2020-07-22 ms5000001810105069

    挖掘

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1698125, encodeId=b30f1698125c4, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Aug 19 08:29:50 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796997, encodeId=07bb1e96997d9, content=<a href='/topic/show?id=5a6e221853a' target=_blank style='color:#2F92EE;'>#中心静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22185, encryptionId=5a6e221853a, topicName=中心静脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sat Jun 05 03:29:50 CST 2021, time=2021-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900620, encodeId=094490062032, content=哪来那么大的样本量, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=464e4070825, createdName=898319336, createdTime=Thu Nov 19 21:39:32 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715615, encodeId=bbac1e156156f, content=<a href='/topic/show?id=83622218699' target=_blank style='color:#2F92EE;'>#中心静脉压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22186, encryptionId=83622218699, topicName=中心静脉压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5631964592, createdName=ms4657536712156177, createdTime=Sun Aug 09 22:29:50 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803888, encodeId=d28580388807, content=挖掘, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c605377477, createdName=ms5000001810105069, createdTime=Wed Jul 22 13:03:55 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516382, encodeId=e7bf15163820d, content=<a href='/topic/show?id=a5598519866' target=_blank style='color:#2F92EE;'>#脓毒症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85198, encryptionId=a5598519866, topicName=脓毒症患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dd7310955580, createdName=dlwang_26703130, createdTime=Tue Jul 21 07:29:50 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803342, encodeId=11fb803342cb, content=<a href='/topic/show?id=9d1523811e6' target=_blank style='color:#2F92EE;'>#乳酸#</a>对于重症至关重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23811, encryptionId=9d1523811e6, topicName=乳酸)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Jul 19 16:51:47 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803341, encodeId=739480334194, content=<a href='/topic/show?id=7a2f851921d' target=_blank style='color:#2F92EE;'>#脓毒症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85192, encryptionId=7a2f851921d, topicName=脓毒症)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Jul 19 16:51:07 CST 2020, time=2020-07-19, status=1, ipAttribution=)]
    2020-07-19 lovetcm

    #乳酸#对于重症至关重要

    0

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    2020-07-19 lovetcm

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