Chest:阻塞性睡眠呼吸暂停的手术患者术后吸氧有好处吗?

2016-12-25 haofan MedSci原创

术后补充氧气可以改善氧合和减少AHI,并不增加呼吸暂停低通气事件的持续时间或PtcCO2水平。当补充氧气时少数患者出现显著的CO2潴留。

阻塞性睡眠呼吸暂停(OSA)的手术患者在围手术期并发症的风险增加,术后补充氧气是常用的手段,但它可能会导致服用阿片类药物的OSA患者呼吸抑制。近日,呼吸疾病领域权威杂志Chest杂志上发表了一篇研究文章,该研究旨在探讨术后吸氧对未经治疗的OSA患者血氧饱和度、睡眠呼吸事件和CO2水平的影响。

该研究纳入的患者必须满足术前多导睡眠图检测到呼吸暂停低通气指数(AHI)>5次/h,这些患者被随机(按1:1)分组,分别接受氧气(O2组)或没有氧气(对照组)处理。O2组术后3天通过鼻管按3L/min吸氧。主要指标包括多导睡眠图参数测量血氧饱和度、睡眠呼吸事件和术后1-3天晚上通过经皮CO2监测仪得到的PCO2(PtcCO2)。研究人员进行了治疗意向性分析和遵照试验协议分析。

该研究共有123例患者进行随机分组;O2组为62名,对照组为61名。在术后第3晚,O2组与对照组相比有较高的平均血氧饱和度:95.2±3% vs. 91.4±4%(P<0.001)和较低的低氧指数:2.3(0.2,13.8)vs. 18.5(8.2,45.9)次/h[平均值(第25、第75百分位数),P<0.0001]。


O2组AHI 8(2.1,19.9)vs. 15.6(9.5,45.8)(P=0.016);低通气指数(P<0.001)、中枢性呼吸暂停指数(P=0.026)有所降低,以及最长呼吸暂停时间有所缩短(P=0.002)。虽然在术后第1、2或3晚中11.4%的患者PtcCO2-CT55≥10%,而组间PtcCO2没有差异。

由此可见,术后补充氧气可以改善氧合和减少AHI,并不增加呼吸暂停低通气事件的持续时间或PtcCO2水平,当补充氧气时少数患者出现显著的CO2潴留。

原始出处:


Pu Liao, et al.Postoperative Oxygen Therapy in Patients with Obstructive Sleep Apnea: A Randomized Controlled Trial. Chest. 2016.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1929263, encodeId=670c19292632f, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Mon Jun 26 22:19:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050573, encodeId=207f20505e34a, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Mar 17 13:19:00 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989028, encodeId=61081989028d1, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Jan 24 21:19:00 CST 2017, time=2017-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696692, encodeId=9aa616966922d, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Thu Mar 30 17:19:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596479, encodeId=036915964e9e6, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Tue Dec 27 10:19:00 CST 2016, time=2016-12-27, status=1, ipAttribution=)]
    2017-06-26 Smile2680
  2. [GetPortalCommentsPageByObjectIdResponse(id=1929263, encodeId=670c19292632f, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Mon Jun 26 22:19:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050573, encodeId=207f20505e34a, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Mar 17 13:19:00 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989028, encodeId=61081989028d1, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Jan 24 21:19:00 CST 2017, time=2017-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696692, encodeId=9aa616966922d, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Thu Mar 30 17:19:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596479, encodeId=036915964e9e6, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Tue Dec 27 10:19:00 CST 2016, time=2016-12-27, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1929263, encodeId=670c19292632f, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Mon Jun 26 22:19:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050573, encodeId=207f20505e34a, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Mar 17 13:19:00 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989028, encodeId=61081989028d1, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Jan 24 21:19:00 CST 2017, time=2017-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696692, encodeId=9aa616966922d, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Thu Mar 30 17:19:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596479, encodeId=036915964e9e6, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Tue Dec 27 10:19:00 CST 2016, time=2016-12-27, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1929263, encodeId=670c19292632f, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Mon Jun 26 22:19:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050573, encodeId=207f20505e34a, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Mar 17 13:19:00 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989028, encodeId=61081989028d1, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Jan 24 21:19:00 CST 2017, time=2017-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696692, encodeId=9aa616966922d, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Thu Mar 30 17:19:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596479, encodeId=036915964e9e6, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Tue Dec 27 10:19:00 CST 2016, time=2016-12-27, status=1, ipAttribution=)]
    2017-03-30 tomyang96
  5. [GetPortalCommentsPageByObjectIdResponse(id=1929263, encodeId=670c19292632f, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Mon Jun 26 22:19:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050573, encodeId=207f20505e34a, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Mar 17 13:19:00 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989028, encodeId=61081989028d1, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Jan 24 21:19:00 CST 2017, time=2017-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696692, encodeId=9aa616966922d, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Thu Mar 30 17:19:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596479, encodeId=036915964e9e6, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Tue Dec 27 10:19:00 CST 2016, time=2016-12-27, status=1, ipAttribution=)]

相关资讯

J Glaucoma:阻塞性睡眠呼吸暂停与视网膜神经纤维层厚度有关(荟萃分析)

近期发表在J Glaucoma的研究称,睡眠呼吸暂停综合症(OSAS)会增加视网膜神经纤维层厚度损失风险。我国学者珠海中山大学的研究人员对2011-2014年的6项研究(涉及1034只眼睛)进行了荟萃分析,纳入的研究评估了至少一项以下数据:平均视网膜神经纤维层(RNFL)厚度、四象限(上、鼻、下、颞)RNFL厚度、OSAS不同阶段的RNFL厚度。排除了可疑或确证青光眼、视神经炎、慢性葡萄膜炎、视网

J Clin Sleep Med:阻塞性睡眠呼吸暂停不只是肥胖才会发生的疾病

本研究旨在确定非肥胖人群阻塞性睡眠呼吸暂停(OSA)的比例和生理特性及其对治疗的反应。研究纳入来源于学院教学医院睡眠门诊的疑似OSA的患者。评估基线及随访期间(至22个月)研究对象的睡眠和人体测量参数,并比较肥胖和非肥胖研究对象中OSA的诊断(睡眠期间呼吸暂停低通气指数> 5次/小时)。对比两组间促进OSA发生的关键非解剖因素和呼吸兴奋阈值。结果,25%的OSA患者其身体质量指数(BMI)在

SLEEP:阻塞性睡眠呼吸暂停和认知能力下降之间的关系

目标既往一些评估睡眠质量异常与认知能力下降的前瞻性数据的准确性和数量是有限的,因为大多数研究使用主观数据和/或短期随访。我们假设,在15年的随访时间中,相比睡眠正常的参与者而言,患有OSA和睡眠质量差的参与者认知功能下降更甚。 方式研究人员为ARIC参与者(n=966,平均年龄为61岁,55%为女性)进行家庭式多导睡眠描记术检查(1996-1998),并在之后15年随访中进行重复认知测试。研究人员

NEJM:持续气道正压通气并不能预防阻塞性睡眠呼吸暂停患者心血管事件的发生

阻塞性睡眠呼吸暂停与心血管事件的发生风险增加有关;持续气道正压通气(CPAP)治疗是否可预防重达心血管事件的发生则尚未确定。 研究共纳入了2717名合格的成年人,年龄在45岁到75岁之间,患有中度至重度阻塞性睡眠呼吸暂停及冠状动脉或脑血管疾病。将其随机分配分别接受CPAP治疗加常规治疗(CPAP组)或常规治疗(常规护理组)。 主要的复合终点是因心血管疾病死亡,心肌梗死,中风,或住院治疗

JAHA:阻塞性睡眠呼吸暂停与循环钾通道水平的关系

由此可见,大多数钾通道mRNA表达与阻塞性睡眠呼吸暂停的严重程度和低氧血症呈负相关。持续气道正压通气治疗可以改善中度阻塞性睡眠呼吸暂停患者循环KCNQ1、KCNJ2表达水平。

盘点:不容忽视的阻塞性睡眠呼吸暂停

阻塞性睡眠呼吸暂停是睡眠过程中上气道反复塌陷,造成血氧饱和度下降以及睡眠中断,正成为越来越常见的疾病。其症状包括打鼾、呼吸暂停以及白天嗜睡。阻塞性睡眠呼吸暂停的发病机制各异,易感因素包括上呼吸气道狭小、 呼吸调节不稳定、 唤醒阈值低、肺容量小和上呼吸道扩张肌功能失调。 危险因素包括肥胖、 男性、 年龄、 更年期、 体液潴留、 扁桃体肥大和吸烟。阻塞性睡眠呼吸暂停能引起白天嗜睡、 道路