AHA 2014:缺氧和低血压对外伤性脑损伤有协同负面效应

2014-11-20 高晓方 译 医学论坛网

AHA 2014科学年会的一项报告表明,院前缺氧和低血压可对外伤性脑损伤(TBI)患者产生协同负面效应,导致死亡风险相对于单一因素显著升高3倍以上。14 此项研究共纳入9194例中重度TBI患者,并以氧饱和度<90%定义缺氧,以收缩压<90 mmHg定义低血压。对年龄、性别、种族、付款来源和创伤治疗中心等混淆因素进行校正之后,利用比值比(OR)评估死亡率与缺氧和/或低血压之间

AHA 2014科学年会的一项报告表明,院前缺氧低血压可对外伤性脑损伤(TBI)患者产生协同负面效应,导致死亡风险相对于单一因素显著升高3倍以上。14

此项研究共纳入9194例中重度TBI患者,并以氧饱和度<90%定义缺氧,以收缩压<90 mmHg定义低血压。对年龄、性别、种族、付款来源和创伤治疗中心等混淆因素进行校正之后,利用比值比(OR)评估死亡率与缺氧和/或低血压之间的相关性。同时将对TBI治疗指南实施前后的诊治情况加以评估。

结果显示,大部分患者(88.2%)既无缺氧也无低血压,同时伴有缺氧和高血压的患者为131例(1.4%),仅有缺氧的患者和仅有低血压的患者分别为535例(5.8%)和419例(4.6%)。院前缺氧和低血压均与死亡率显著升高具有相关性。仅缺氧或低血压患者的死亡率分别为29.7%(OR 4.1)和21.8%(OR 3.0),缺氧联合低血压患者则为50.6%(OR13.8)。TBI患者的理想血压为144 mmHg。积极治疗缺氧和低血压的前瞻性干预试验仍在进行之中。

挪威奥斯陆大学医院Olasveengen博士表示,缺氧和低血压与TBI患者不良转归的相关性并不令人吃惊,未来需进一步评估缺氧/低血压能够在何种程度上作为严重损伤患者的标志物,以及其是否代表了改善患者转归的真正干预时机。

英文链接:Hypoxia, Hypotension 'Deadly Combo' in TBI


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