Diabetologia:医护人员轮岗值班期间的葡萄糖代谢

2017-07-31 MedSci MedSci原创

研究人员使用随机交叉研究设计研究了12名健康护士进行轮岗值班。在每次场合,参与者在模拟日班和模拟夜班进行同位素标记的混合餐测试,使用口服最小模型同时测量葡萄糖通量和β细胞功能。研究人员试图确定白天与夜班期间空腹血糖和餐后葡萄糖代谢的差异。

近日,国际杂志 《Diabetologia》上在线发表一项关于医护人员轮岗值班期间的葡萄糖代谢的研究。

值班与昼夜节律紊乱和肥胖、2糖尿病风险增加有关。研究人员试图确定值班对人体葡萄糖代谢的影响。

研究人员使用随机交叉研究设计研究了12名健康护士进行轮岗值班。在每次场合,参与者在模拟日班和模拟夜班进行同位素标记的混合餐测试,使用口服最小模型同时测量葡萄糖通量和β细胞功能。研究人员试图确定白天与夜班期间空腹血糖和餐后葡萄糖代谢的差异。

夜间班次餐后血糖偏高(381±33 vs 580±48 mmol/l / 5 hp <0.01)。在晚班时间内,胰岛素、C肽和最低胰高血糖素抑制峰值的时间与食物吸收一样也被推迟。虽然胰岛素活动在日夜班没有差异,但在夜间,β细胞对葡萄糖的反应性(59±5 vs 44±4×10-9min-1 p <0.001)和处理指数均降低。

夜间β细胞功能受损可能是正常的昼夜变化,轮班的影响或两者的结合。因此,观察到了夜间较高的餐后葡萄糖浓度。

原始出处:

Anu Sharma, Marcello C. Laurenti,et al. Glucose metabolism during rotational shift-work in healthcare workers

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    2017-08-10 yfjms

    值班有害健康

    0

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  5. 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  6. 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Tue Aug 01 23:09:23 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228626, encodeId=276e228626fb, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Tue Aug 01 04:00:24 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228611, encodeId=1086228611f9, content=值夜班有损健康啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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    2017-08-02 yinxm8305
  7. 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  8. 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authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Tue Aug 01 00:58:43 CST 2017, time=2017-08-01, status=1, ipAttribution=)]
    2017-08-01 131****2916

    不错的文章值得学习

    0

  9. 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    2017-08-01 189****7206

    学习了受益匪浅

    0

  10. 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    2017-08-01 lyh994

    值夜班有损健康啊

    0

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