Stroke:产后住院分娩感染显著增加30天内再入院风险

2019-09-26 国际循环编辑部 国际循环

妊娠相关性缺血性卒中(IS)和出血性卒中(HS)多发生在产后。临床已确认,感染是年轻患者卒中发作的诱因,并与分娩住院期间的卒中有关,但二者是否具有直接相关性仍不清楚。近期,Stroke杂志发表研究,评估分娩入院期间确诊感染与产后卒中再入院风险的相关性。

妊娠相关性缺血性卒中(IS)和出血性卒中(HS)多发生在产后。临床已确认,感染是年轻患者卒中发作的诱因,并与分娩住院期间的卒中有关,但二者是否具有直接相关性仍不清楚。近期,Stroke杂志发表研究,评估分娩入院期间确诊感染与产后卒中再入院风险的相关性。

研究人员以国家医疗成本与利用再入院数据库2010~2014年的数据为基础,进行一项回顾性队列研究,使用加权调查设计Poisson回归分析,计算分娩期间感染与产后30天因IS或HS再入院之间相关性的调整风险比(ARR)和95%置信区间(95%CI)。

在研究期间的1720万例分娩入院患者中,30天内因任意类型卒中再入院2128例,其中HS(脑出血或蛛网膜下腔出血)1189例和IS720例,其余为其他类型妊娠相关卒中。考虑到年龄和合并症状况,分娩感染的女性在任何类型产后卒中方面均有较高的再入院风险(ARR=1.19;95%CI:1.01~1.41),感染女性产后再入院风险较高(ARR=1.75;95%CI:1.37~2.22),但产后HS风险不高(ARR=0.96;95%CI:0.75~1.23),无妊娠高血压的女性在30天内因感染再次入院风险更高(ARR=2.0;95%CI:1.55~2.69;妊娠高血压女性患者ARR=1.47;95%CI:0.9~2.38,P=0.09)。

分娩期间感染住院与产后30天内IS(而非HS)再入院风险增加相关,这在没有妊娠高血压的孕产妇中更显著。此外,上述研究还显示,即使没有合并其他危险因素,感染也可引发产后IS。

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    2019-09-28 linlin2312
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    2019-09-27 一个字-牛

    学习了谢谢分享

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