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Sci Signal：TFEB抑制内皮细胞炎症并减轻动脉粥样硬化

2017-03-30 MedSci MedSci原创

TFEB动脉粥样硬化内皮细胞自噬溶酶体
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转录因子EB（TFEB）是自噬和溶酶体发生的主要调节因子。近日美国密歇根大学学者发表文章于Sci Signal，以探讨TFEB在血管生物学和病理生理学中的功能，并证明TFEB在内皮细胞中抑制炎症和减轻动脉粥样硬化发展。保护动脉粥样硬化的层流剪切应力可增加原代人内皮细胞中TFEB表达。此外，在这些细胞中，TFEB的过表达抗炎，而TFEB敲低则加剧了炎症。TFEB的抗炎作用至少部分是通过氧化应激性降低

转录因子EB（TFEB）是自噬和溶酶体发生的主要调节因子。近日美国密歇根大学学者发表文章于Sci Signal，以探讨TFEB在血管生物学和病理生理学中的功能，并证明TFEB在内皮细胞中抑制炎症和减轻动脉粥样硬化发展。

保护动脉粥样硬化的层流剪切应力可增加原代人内皮细胞中TFEB表达。此外，在这些细胞中，TFEB的过表达抗炎，而TFEB敲低则加剧了炎症。TFEB的抗炎作用至少部分是通过氧化应激性降低，因为TFEB在内皮细胞中过度表达降低了活性氧的浓度，增加了抗氧化基因HO1（其编码血红素加氧酶1）和SOD2的表达（其编码超氧化物歧化酶2）。而且内皮细胞特异性过表达的TFEB转基因小鼠表现出内皮细胞白细胞募集减少，并减少动脉粥样硬化发展。

研究结果表明TFEB是内皮细胞炎症的保护性转录因子和治疗动脉粥样硬化和相关心血管疾病的潜在靶标。

原始出处：Lu H， Fan Y， et al. TFEB inhibits endothelial cell inflammation and reduces atherosclerosis. Sci Signal. 2017 Jan 31；10(464). pii： eaah4214.

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    2017-10-26 楚秀娟

    #Sign#

    0

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    2018-02-17 智者为医08

    #Signal#

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    2017-06-20 huangshifeng

    #粥样硬化#

    0

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    2017-09-13 wushaoling

    #细胞炎症#

    0

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    2017-03-30 jin321

    期待好的效果，媲美他听类

    0

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    2017-03-29 1ddf0692m34(暂无匿称)

    涨知识，值得分享

    0

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    2017-03-29 cqykthl

    内皮细胞白细胞减少

    0

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