Eur Heart J:道路交通噪音与心血管疾病风险因素的相关性

2021-03-19 Nebula MedSci原创

居住在地铁旁、高架桥、铁道附近对心血管疾病风险有怎样的影响?

道路交通噪声是血管疾病(CVD)的一个重要的环境风险因素,但其潜在的生物机制仍未完全阐明。

本研究旨在调查英国生物库中模拟住宅道路交通噪声与CVD风险因素(收缩压[SBP]和舒张压[DBP]、C-反应蛋白、甘油三酯、糖化血红蛋白和自报高血压)之间的横断面关联。

2006-10年间,英国生物库在全国招募了502651名40-69岁的人。采用“通用噪声评估方法“”模型的简化版本在基线住址估算2009年的道路交通噪声(Lden和Lnight)暴露量。采用多变量线性和Logistic回归模型,调整了年龄、性别、体重指数(BMI)、吸烟、饮酒、地区和个人水平剥夺、抽血季节、居住时间和二氧化氮(主要模型),分析样本量超过了37万人。

道路Lden与心血管风险因素变化百分比的相关性

与道路交通噪声Lden≤55dB[A]相比,道路交通噪声暴露Lden>65dB[A]的个体的收缩压、舒张压、甘油三酯和糖化血红蛋白分别高出0.77%[95%CI 0.60%-0.95%]、0.49%(0.32%-0.65%)、0.79%(0.11%-1.47%)和0.12%(0.04%-0.28%)。

与道路交通噪声暴露相关的收缩压和舒张压横截面变化

从主模型中剔除BMI与五个具有较高百分比变化的标记物都具有显著的正相关性。与SBP或DBP的相关性似乎不受高血压药物使用的影响,但在暴露于Lden 60-65dB[A]水平的无药物治疗组中,噪音暴露与自我报告的高血压呈正相关(优势比 1.07,95%CI 1.00-1.15)。

综上,道路交通噪声暴露>65dB[A],与血压和心血管生化的小幅度不利变化有关,且独立于二氧化氮之外

原始出处:

Kupcikova Zuzana,Fecht Daniela,Ramakrishnan Rema et al. Road traffic noise and cardiovascular disease risk factors in UK Biobank. Eur Heart J, 2021, 10.1093/eurheartj/ehab121

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    2021-08-22 ms4000001678904427

    噪音污染

    0

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13:32:45 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949656, encodeId=4be8949656e0, content=噪音污染危害不小, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sat Mar 20 06:55:01 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
    2021-08-02 A型夹层

    买房请远离道路😂#学习#

    0

  5. 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13:32:45 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949656, encodeId=4be8949656e0, content=噪音污染危害不小, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sat Mar 20 06:55:01 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
    2021-03-21 zhaojie88
  6. 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13:32:45 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949656, encodeId=4be8949656e0, content=噪音污染危害不小, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sat Mar 20 06:55:01 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
  7. 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13:32:45 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949656, encodeId=4be8949656e0, content=噪音污染危害不小, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sat Mar 20 06:55:01 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1936904, encodeId=80c11936904df, content=<a href='/topic/show?id=b7c62438600' target=_blank style='color:#2F92EE;'>#交通噪音#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24386, encryptionId=b7c62438600, topicName=交通噪音)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d47b2500175, createdName=12498cf9m35(暂无昵称), createdTime=Sun Apr 11 12:32:45 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837913, encodeId=c4aa183e91389, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, 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encodeId=f5b81563425db, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sun Mar 21 13:32:45 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588863, encodeId=13751588863b7, content=<a href='/topic/show?id=00742438078' target=_blank style='color:#2F92EE;'>#交通#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24380, encryptionId=00742438078, topicName=交通)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84fb17623791, createdName=yuandd, createdTime=Sun Mar 21 13:32:45 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949656, encodeId=4be8949656e0, content=噪音污染危害不小, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sat Mar 20 06:55:01 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
    2021-03-21 slcumt
  9. [GetPortalCommentsPageByObjectIdResponse(id=1936904, encodeId=80c11936904df, content=<a href='/topic/show?id=b7c62438600' target=_blank style='color:#2F92EE;'>#交通噪音#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24386, encryptionId=b7c62438600, topicName=交通噪音)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d47b2500175, createdName=12498cf9m35(暂无昵称), createdTime=Sun Apr 11 12:32:45 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837913, encodeId=c4aa183e91389, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, 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13:32:45 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949656, encodeId=4be8949656e0, content=噪音污染危害不小, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sat Mar 20 06:55:01 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
    2021-03-21 yuandd
  10. 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13:32:45 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949656, encodeId=4be8949656e0, content=噪音污染危害不小, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sat Mar 20 06:55:01 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
    2021-03-20 易水河

    噪音污染危害不小

    0

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随着时间的推移,收缩压升高而未达到高血压阈值,则与健康成年人发生CKD的风险增加显著相关。

JAHA:收缩压和动脉僵硬度进展之间的关系

基线收缩压与动脉僵硬度进展有关,与年龄无关。

Circulation:40年,人群高血压控制可提高多少?

美国在上世纪60-70年代就开始了高血压意识、治疗和控制项目。虽然实施相应干预措施后,群众的血压(BP)控制和高血压相关疾病风险降低均有所改善,但目前尚不清楚这些BP变化是否可适用于不同的高危人群。

Stroke:脑出血患者收缩压降低与急性肾损伤

基线血肌酐水平较高和接受较高剂量尼卡地平的脑出血患者发生AKI和肾AE的风险较高。AKI的发生与3个月时较高的死亡率或致残率相关。

收缩压高于90就不正常?美全新分析

一般认为,收缩压从110 mmHg起,血压越高,发生心血管病事件的危险越高。