Radiology:镓68 PSMA-11 PET/MR成像在中高危前列腺癌中的价值

2018-07-27 shaosai MedSci原创

本研究旨在报告双时相镓68(68Ga)PSMA 11PET/MRI在中高危前列腺癌切除术前的诊断价值,将结果发表在radiology上。

本研究旨在报告双时相镓68(68Ga)PSMA 11PET/MRI在中高危前列腺癌切除术前的诊断价值,将结果发表在radiology上。

本研究共纳入了33例前列腺癌并预计行前列腺癌环形切除并淋巴结轻松清扫的患者。 68Ga-PSMA-11平均剂量为4.1 mCi ± 0.7 (151.7 MBq ± 25.9) 。利用GE SIGNA PET/MR扫描仪在注射药物后41-61分钟后进行全身扫描,并在之后的87-125分钟进行盆腔扫描。PET/MR影像学表现与多参数MR成像进行比较,并与病理结果进行相关性分析来得出敏感性和特异性。比较双时相代谢参数,及其与临床和病理组织学的相关性。

结果为,共有33例患者在68Ga -PSMA-11 PET 检出前列腺癌,而MR成像中PI-RADS4或5共有26例,PI-RADS共有4例。共有5例患者盆腔淋巴结出现局部摄取。所有患者经病理证实均为前列腺癌,且有3例患者出现淋巴结转移。在PET/MR中无淋巴结转移的患者病理结果正常。随着采集时间延迟,68Ga-PSMA-11累及增加,且SUVmax (15.3 vs 12.3, P < .001)增加。有1例前列腺癌进展延迟扫描中检出。

本研究表明,68Ga-PSMA-11 PET/MR可用于诊断前列腺癌,磁共振成像能够提供更为清楚的解剖结构。因此68Ga-PSMA-11 PET/MR能够提过有价值的诊断信息,并能提示有无淋巴结转移及切除必要。

原始出处:

Park SY, Zacharias C, Harrison C. et al.Gallium 68 PSMA-11 PET/MR Imaging in Patients with Intermediate- or High-Risk Prostate Cancer.Radiology.DOI:10.1148/radiol.2018172232

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    2019-05-24 feather89
  2. 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    2018-09-27 大爰

    学习了谢谢分享!!

    0

  3. 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    2018-09-05 大爰

    学习了谢谢分享!!

    0

  4. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Jul 31 07:30:34 CST 2018, time=2018-07-31, status=1, ipAttribution=)]
    2018-08-22 大爰

    学习了谢谢分享!!

    0

  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Jul 31 07:30:34 CST 2018, time=2018-07-31, status=1, ipAttribution=)]
    2018-08-05 大爰

    学习了谢谢分享!!

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Thu Aug 02 00:05:14 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335540, encodeId=dc643355401e, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Wed Aug 01 13:32:36 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335253, encodeId=d43933525313, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Jul 31 07:30:34 CST 2018, time=2018-07-31, status=1, ipAttribution=)]
    2018-08-04 liumin1987

    前列腺癌的影像诊断。

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Jul 31 07:30:34 CST 2018, time=2018-07-31, status=1, ipAttribution=)]
    2018-08-02 jihuaijun1112

    学习学习学习

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Jul 31 07:30:34 CST 2018, time=2018-07-31, status=1, ipAttribution=)]
    2018-08-02 jihuaijun1112

    学习学习学习

    0

  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Jul 31 07:30:34 CST 2018, time=2018-07-31, status=1, ipAttribution=)]
    2018-08-01 jihuaijun1112

    学习学习学习

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Thu Aug 02 00:05:14 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335540, encodeId=dc643355401e, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Wed Aug 01 13:32:36 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335253, encodeId=d43933525313, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Jul 31 07:30:34 CST 2018, time=2018-07-31, status=1, ipAttribution=)]
    2018-07-31 jihuaijun1112

    学习学习

    0