DCR: 使用柔性乙状结肠镜可以进行早发性结直肠癌的筛查

2018-07-19 MedSci MedSci原创

美国国家数据库显示50岁以下人群中结直肠癌发病率显着增加。目前的指南建议是在50岁时开始进行结肠癌风险筛查。研究人员发现年轻人中的大多数癌症都是左侧的,这将为通过灵活的乙状结肠镜检查筛查年轻人创造机会。本研究旨在分析50岁以下患者散发性结直肠癌的解剖学分布。

背景:
美国国家数据库显示50岁以下人群中结直肠癌发病率显着增加。目前的指南建议是在50岁时开始进行结肠癌风险筛查。研究人员发现年轻人中的大多数癌症都是左侧的,这将为通过灵活的乙状结肠镜检查筛查年轻人创造机会。本研究旨在分析50岁以下患者散发性结直肠癌的解剖学分布。

方法:
这是一项回顾性研究,纳入了包括2000年至2016年间患有结肠直肠癌的50岁以下患者。而患有IBD,家族性腺瘤性息肉病,Lynch综合征或遗传性非息肉病性结直肠癌的患者被排除在外。主要观察指标是肿瘤位置和分期,

结果:
本项研究共纳入739名患者。诊断时的年龄范围为18至49岁;中位年龄为44岁。520名患者年龄在40至49岁之间,167名年龄在30至39岁之间,40名年龄在20至29岁之间,2名患者在20岁以下.221名患者(32%)患有结直肠癌的家族史。癌症的解剖学分布结果为:485例直肠癌(65%),107例乙状结肠癌(15%),19例降结肠癌(3%)和128例右结肠和横结肠(17%)。因此,理论上83%的肿瘤在乙状结肠镜检查范围内。

结论:
随着结直肠癌发病率越来越高,40岁开始行结直肠癌筛查是积极有效的,而通过乙状结肠镜可以发现无症状的病灶。

原始出处:

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    2018-07-21 zhouqu_8
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    2018-07-20 1ddf0692m34(暂无匿称)

    学习了,长知识

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